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Introduction And Hypothesis: Urinary urgency is the cardinal symptom of overactive bladder (OAB). However, there is no single instrument that assesses the context, severity, intensity, and daily life impact of urinary urgency. The purpose of this manuscript is to describe the methods and results of the qualitative and quantitative research conducted to develop a new tool for this purpose, the Urgency Questionnaire (UQ).
Methods: Qualitative data from interviews with patients with urinary urgency were used to develop and refine the items and response options of the UQ. Three studies were used to evaluate psychometric properties: a clinical trial of tolterodine (Detrol; n = 974); a psychometric validation study (n = 163); and a test-retest validation study (n = 47). Item and exploratory factor analysis (EFA) were performed to assess the subscale structure, and the psychometric performance of the resulting scales was evaluated.
Results: Fifteen Likert-scale items and four VAS questions were retained. A four-factor solution was shown to best fit the data, with the subscales: Impact on Daily Activities, Time to Control Urgency, Nocturia, and Fear of Incontinence. All subscales and VAS items demonstrated good reliability (Cronbach's α 0.79-0.94), convergent and discriminant validity, and responsiveness to change. The UQ differentiated between OAB patients and controls.
Conclusion: The results provide quantitative evidence that urinary urgency, as assessed by the UQ, is a pathological sensation distinctive from the normal urge to void and suggest that the UQ might be a reliable, valid, and responsive instrument for evaluating the severity and HRQL impact of urinary urgency in OAB.
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http://dx.doi.org/10.1007/s00192-014-2435-5 | DOI Listing |
Urogynecology (Phila)
December 2024
Department of Mechanical and Nuclear Engineering, Virginia Commonwealth University, Richmond, VA.
Importance: Functional near-infrared spectroscopy (fNIRS) is a noninvasive technique used to quantify prefrontal cortex (PFC) neuroexcitation. The PFC is involved in the decision to void, and dysfunction in the region has been associated with overactive bladder (OAB). This study demonstrates neuroexcitation differences in the brain region associated with the decision to void (prefrontal cortex) using noninvasive fNIRS.
View Article and Find Full Text PDFBackground: Lupus cystitis, a severe complication of systemic lupus erythematosus (SLE), presents considerable treatment challenges.
Purpose: This case report describes the use of telitacicept in treating severe SLE with lupus cystitis.
Research Design: A single patient with lupus cystitis.
Cochrane Database Syst Rev
December 2024
Rehabilitation Teaching and Research Unit, Department of Medicine, University of Otago, Wellington, New Zealand.
Background: Pelvic floor muscle training (PFMT) is a recommended treatment for female stress, urgency, and mixed urinary incontinence. Training varies in exercise type (pelvic floor muscles contracting with and without other muscles), dose, and delivery (e.g.
View Article and Find Full Text PDFBMC Urol
December 2024
Division of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 16F, #289, Chienkuo Road, Xindian, New Taipei, 23142, Taiwan.
Purpose: The purpose of this study was to compare the differences in lower urinary tract function and treatment response between non-monosymptomatic nocturnal enuresis (NMNE) pediatric patients with and without constipation.
Method: We retrospectively analyzed pediatric patients diagnosed as NMNE from our enuresis database. Inclusion criteria were children aged 5 years or older with a follow-up duration of at least one month.
Purpose: To assess efficacy and safety of URO-902, an investigational gene therapy expressing the α subunit of the large-conductance Ca-activated K channel, in a phase 2a placebo-controlled trial in women with overactive bladder (OAB).
Materials And Methods: Women, 40‒79 years, with OAB and urge urinary incontinence (UUI) who were refractory to OAB medications were randomized to single-dose URO-902 24 and 48 mg or placebo administered by intradetrusor injection via cystoscopy under local anesthesia. Efficacy endpoints included change from baseline to week 12 in mean daily micturitions, urgency episodes, UUI episodes, and patient-reported outcomes.
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