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Fibroblast activation protein peptide-targeted NIR-I/II fluorescence imaging for stable and functional detection of hepatocellular carcinoma.
Eur J Nucl Med Mol Imaging
January 2025
Department of Hepatobiliary Surgery and Liver Transplantation Center, The Fifth Affiliated Hospital of Sun Yat-Sen University, 52 Mei Hua East Road, Zhuhai, 519000, China.
Purpose: Cancer-associated fibroblasts (CAFs) are the primary stromal component of the tumor microenvironment in hepatocellular carcinoma (HCC), affecting tumor progression and post-resection recurrence. Fibroblast activation protein (FAP) is a key biomarker of CAFs. However, there is limited evidence on using FAP as a target in near-infrared (NIR) fluorescence imaging for HCC.
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Juan M. Salgado, MD, Department of Anesthesiology, University of Kansas School of Medicine-Wichita, Wichita, Kansas. He was responsible for concept initiation, presenting the seminar and workshop, data collection and analysis, drafting the manuscript, and approval of the final manuscript.
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View Article and Find Full Text PDFThe Role of Proton Magnetic Resonance Spectroscopy in Neonatal and Fetal Brain Research.
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The biochemical composition and structure of the brain are in a rapid change during the exuberant stage of fetal and neonatal development. H-MRS is a noninvasive tool that can evaluate brain metabolites in healthy fetuses and infants as well as those with neurological diseases. This review aims to provide readers with an understanding of 1) the basic principles and technical considerations relevant to H-MRS in the fetal-neonatal brain and 2) the role of H-MRS in early fetal-neonatal development brain research.
View Article and Find Full Text PDFUnconstitutionality of the income tax calculation when offsetting foreign taxes with regard to the exemption of the subsistence minimum? A quantitative analysis.
Heliyon
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IU International University of Applied Sciences Germany, Erfurt; Open Access Publication Enabled By IU International University of Applied Sciences, Germany.
The present study addresses a previously unexamined question of whether the calculation of income tax in the case of foreign tax credits violates constitutional law. Methodologically, this is investigated via quantitative analysis. As part of a quantitative analysis it is shown that the current method of calculating income tax when offsetting foreign taxes violates constitutional law in the form of the subjective net principle, as the taxpayer loses part of the tax-effective basic allowance deduction due to the calculation method; thus, the minimum subsistence level is no longer fully exempt from taxation with income tax.
View Article and Find Full Text PDFObservation of Extraordinary Vibration Scatterings Induced by Strong Anharmonicity in Lead-Free Halide Double Perovskites.
Adv Sci (Weinh)
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Department of Mechanical and Aerospace Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, Hong Kong.
Lead-free halide double perovskites provide a promising solution for the long-standing issues of lead-containing halide perovskites, i.e., the toxicity of Pb and the low stability under ambient conditions and high-intensity illumination.
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