AI Article Synopsis
- The Rh(II) catalyst effectively promotes the addition of nitrenes to alkenes, producing vicinal amino alcohols with high yields (up to 95%) and full regioselectivity.
- This process, known as 1,2-oxyamination, forms an aziridine intermediate that subsequently opens its ring.
- The ring opening is facilitated by the Rh-bound nitrene, which acts as a Lewis acid in the reaction.
Article Abstract
The Rh(II)-catalyzed intermolecular addition of nitrenes to aromatic and aliphatic alkenes provides vicinal amino alcohols with yields of up to 95 % and complete regioselectivity. This 1,2-oxyamination reaction involves the formation of an aziridine intermediate that undergoes in situ ring opening. The latter is induced by the Rh-bound nitrene that behaves as a Lewis acid.
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| http://dx.doi.org/10.1002/chem.201400301 | DOI Listing |
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