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Targeting BCAA metabolism to potentiate metformin's therapeutic efficacy in the treatment of diabetes in mice.
Diabetologia
November 2023
Department of Immunology, Key Laboratory of Immune Microenvironment and Disease of the Educational Ministry of China, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
Aims/hypothesis: An increasing body of evidence has shown that the catabolism of branched-chain amino acids (BCAAs; leucine, isoleucine and valine) is impaired in obese animals and humans, contributing to the development of insulin resistance and type 2 diabetes. Promoting BCAA catabolism benefits glycaemic control. It remains unclear whether BCAA catabolism plays a role in the therapeutic efficacy of currently used glucose-lowering drugs such as metformin.
View Article and Find Full Text PDFDPP-4 inhibition resembles exercise in preventing type 2 diabetes development by inhibiting hepatic protein kinase C expression in a mouse model of hyperinsulinemia.
J Int Med Res
June 2020
Military Postgraduate Medical College, Second Medical Center of PLA General Hospital, Beijing, China.
Article Synopsis
- The study focuses on how a drug called DPP-4 inhibitor can help prevent hyperinsulinemia (HINS), which is a warning sign for type 2 diabetes.
- Researchers used special mice to test the drug and also looked at how exercise affects HINS.
- The results showed that both exercise and the DPP-4 inhibitor helped reduce fat in the liver and improved how insulin works, which could delay the chances of getting type 2 diabetes.
Development and evaluation of a real-time RT-PCR and a field-deployable RT-insulated isothermal PCR for the detection of Seneca Valley virus.
BMC Vet Res
May 2019
GeneReach USA, Lexington, MA, USA.
Background: Seneca Valley virus (SVV) has emerged in multiple countries in recent years. SVV infection can cause vesicular lesions clinically indistinguishable from those caused by other vesicular disease viruses, such as foot-and-mouth disease virus (FMDV), swine vesicular disease virus (SVDV), vesicular stomatitis virus (VSV), and vesicular exanthema of swine virus (VESV). Sensitive and specific RT-PCR assays for the SVV detection is necessary for differential diagnosis.
View Article and Find Full Text PDFLong-term functional change of cryoinjury-induced detrusor underactivity and effects of extracorporeal shock wave therapy in a rat model.
Int Urol Nephrol
April 2019
Department of Urology, Oakland University-William Beaumont School of Medicine, Detroit, USA.
Purpose: To investigate the long-term functional change of cryoinjury-induced detrusor underactivity (DU) and the therapeutic potential of repeated low-energy shock wave therapy (LESW).
Methods: Fifty-six female Sprague-Dawley rats were assigned into sham and cryoinjury of bladder with or without LESW (0.05 or 0.
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