AI Article Synopsis
- - Using various experimental methods, researchers found that growth hormone (GH) is produced locally by human mammary cells when stimulated by progesterone.
- - GH promotes the growth of a specific group of cells that have characteristics of stem and early progenitor cells and express growth hormone receptors (GHR).
- - In 72% of cases with ductal carcinoma in situ, there was an increase in cells that express GHR, indicating that GH signaling could play a role in breast cancer development.
Article Abstract
Using in vitro and in vivo experimental systems and in situ analysis, we show that growth hormone (GH) is secreted locally by normal human mammary epithelial cells upon progesterone stimulation. GH increases proliferation of a subset of cells that express growth hormone receptor (GHR) and have functional properties of stem and early progenitor cells. In 72% of ductal carcinoma in situ lesions, an expansion of the cell population that expresses GHR was observed, suggesting that GH signaling may contribute to breast cancer development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050343 | PMC |
| http://dx.doi.org/10.1016/j.stemcr.2014.05.005 | DOI Listing |
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