Oral Administration of T Cell Epitope Peptide Inhibits the Systemic IL-4 Response Elicited by an Egg-White Diet in a TCR Transgenic Mouse Model.

Biosci Microbiota Food Health

Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan ; Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.

Published: June 2014

Oral immunotherapy with T cell epitope peptides is a promising treatment for food allergy. We examined the effect of oral administration of an ovalbumin T cell epitope peptide (OVA323-339) in a TCR transgenic mouse model (OVA23-3 mice). OVA23-3 mice were fed egg-white diet containing ovalbumin and subsequently orally administrated the OVA323-339 peptide. Cytokine measurements revealed that the IL-4 production of splenic CD4(+) T cells was significantly decreased by feeding the OVA323-339 peptide. Our study suggested that oral administration of the OVA323-339 T cell epitope peptide was capable of inhibiting systemic IL-4 response after elicitation of predominant Th2 responses.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034323PMC
http://dx.doi.org/10.12938/bmfh.33.47DOI Listing

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