Three new compounds, hypoxyloamide (1), 8-methoxynaphthalene-1,7-diol (2), and hypoxylonol (3), together with seven compounds isolated from nature for the first time, investiamide (4), hypoxypropanamide (5), hypoxylonol A (6), investienol (7), 2-heptylfuran (8), (3S)-5-methyl-8-O-methylmellein (9), (4R)-O-methylsclerone (10), along with 19 known compounds, 11-29, were isolated from the culture broth of Hypoxylon investiens BCRC 10F0115, a fungal endophyte residing in the stems of an endemic Formosan plant Litsea akoensis var. chitouchiaoensis. The structures of the new compounds were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D- and 2D-NMR techniques. Of these isolates, 2, 8-methoxynaphthalen-1-ol (15), and 1,8-dimethoxynaphthalene (16) showed nitric oxide (NO) inhibitory activity with IC50 values of 11.8±0.9, 17.8±1.1, and 13.3±0.5 μM, respectively, stronger than the positive control quercetin (IC50 36.8±1.3 μM). Compounds 2, 15, and 16 also showed interleukin-6 (IL-6) inhibitory activity with IC50 values of 9.2±1.7, 18.0±0.6, and 2.0±0.1 μM, stronger than the positive control quercetin (IC50 31.3±1.6 μM). To the best of our knowledge, this is the first report on guaiane sesquiterpene metabolites, 3, 6, and 7, from the genus Hypoxylon.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.201300364 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Isolation and Identification of Pigment-Producing Endophytic Fungi from the Amazonian Species .
J Fungi (Basel)
January 2024
Programa de Pós-Graduação em Biodiversidade e Biotecnologia, Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus 69050-010, Brazil.
Pigments of fungal origin have aroused increasing interest in the food dye and cosmetic industries since the global demand for natural dyes has grown. Endophytic microorganisms are a source of bioactive compounds, and Amazonian plant species can harbor fungi with a wide range of biotechnological applications. Popularly known in Brazil as crajiru, is a medicinal plant that produces a red pigment.
View Article and Find Full Text PDFEndolichenic fungal diversity associated with some lichens of the Western Ghats.
Planta Med
September 2020
Vivekananda Institute of Tropical Mycology (VINSTROM), Ramakrishna Mission Vidyapith, Chennai, India.
A total of 389 strains of fungi belonging to 38 species were isolated from 10 lichen species of the Western Ghats, southern India. All the lichens screened, irrespective of their growth forms or location, harboured endolichenic fungi. Most of the fungi belonged to the Ascomycotina.
View Article and Find Full Text PDFNew α-pyrones from an endophytic fungus, J2.
RSC Adv
August 2019
Department of Natural Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Qingdao University Qingdao 266021 People's Republic of China +86-532-8299-1172.
Four new α-pyrones, hypotiens A-D (1-4), were isolated from a fungal endophyte, J2, harbored in the medicinal plant . Their structures were determined through detailed HRMS and NMR spectroscopic data. Compounds 1-4 are new α-pyrone derivatives containing an unusual dimethyl substitution in the highly unsaturated side chain.
View Article and Find Full Text PDFInhibitory effects of constituents of an endophytic fungus Hypoxylon investiens on nitric oxide and interleukin-6 production in RAW264.7 macrophages.
Chem Biodivers
June 2014
Graduate Institute of Natural Products (GINP), College of Pharmacy, Kaohsiung Medical University (KMU), Kaohsiung 807, Taiwan, ROC, (phone: +886-7-3121101 (ext 2191)).
Three new compounds, hypoxyloamide (1), 8-methoxynaphthalene-1,7-diol (2), and hypoxylonol (3), together with seven compounds isolated from nature for the first time, investiamide (4), hypoxypropanamide (5), hypoxylonol A (6), investienol (7), 2-heptylfuran (8), (3S)-5-methyl-8-O-methylmellein (9), (4R)-O-methylsclerone (10), along with 19 known compounds, 11-29, were isolated from the culture broth of Hypoxylon investiens BCRC 10F0115, a fungal endophyte residing in the stems of an endemic Formosan plant Litsea akoensis var. chitouchiaoensis. The structures of the new compounds were established by spectroscopic methods, including UV, IR, HR-ESI-MS, and extensive 1D- and 2D-NMR techniques.
View Article and Find Full Text PDFHypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a pantropical insecticide-producing endophyte.
PLoS One
May 2013
Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain.
Article Synopsis
- Nodulisporic acids (NAs) are potent metabolites from a specific type of asexual fungal strain known as Nodulisporium, which show effectiveness in treating flea and tick infestations in pets.
- Research has identified that endophytic strains producing NAs are closely related to a wood-inhabiting fungus from Martinique, leading to the hypothesis that a new species, Hypoxylon pulicicidum, should be recognized based on its distinct characteristics.
- Understanding the life cycle of H. pulicicidum will provide insights into the insecticidal properties of these fungi, their impact on living trees, and their colonization of wood, highlighting the importance of lifecycle studies in fungal
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!