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A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly.
Clin Pharmacokinet
December 2024
Department of Anesthesiology, University of Groningen, University Medical Center Groningen, P. O. Box 30001, 9700 RB, Groningen, The Netherlands.
Background And Objectives: The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP (f). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single model to simultaneously describe the PK of PIP/TAZ in diverse patient populations and evaluate the current dosing recommendations by predicting the PK/pharmacodynamics (PD) target attainment throughout life.
View Article and Find Full Text PDFAgreement between self-reported and objectively measured hypertension diagnosis and control: evidence from a nationally representative sample of community-dwelling middle-aged and older adults in China.
Arch Public Health
December 2024
School of Economics and Finance, Xi'an Jiaotong University, No 74 West Yanta Road, Yanta District, Xi'an, Shaanxi, 710061, PR China.
Background: As the population ages, hypertension has become the leading risk factor for cardiovascular diseases (CVDs) and premature deaths worldwide. Accurate monitoring of CVD risks and planning community-based public health interventions require reliable estimates of hypertension prevalence and management. While the validity of self-reporting in assessing hypertension prevalence has been debated, the concordance between self-reports and clinical measurements of hypertension control remains underexplored, particularly in large, community-based older populations.
View Article and Find Full Text PDFIndocyanine Green Lymphography in Conservative Lymphedema Management: An Exploration of the Impact on Lymphedema Therapy Plans.
Semin Oncol Nurs
December 2024
Occupational Therapy Department, Princess Alexandra Hospital, and The School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia.
Objectives: Information from indocyanine green (ICG) lymphography (ICG-L) can be used to guide an individual's lymphedema therapy plan. However, the mechanisms for this clinical translation are not well described. This study proposes a novel clinical decision support tool for translating ICG-L findings into individualized lymphedema therapy plans and describes subsequent changes in plan features of manual lymphatic drainage and compression.
View Article and Find Full Text PDFAdherence, risk perception, and attitudes towards colorectal cancer screening: A road to individualized screening?
Dig Liver Dis
December 2024
MEDCIDS, Faculty of Medicine, University of Porto, Portugal; Gastroenterology Department, RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Centre (Porto.CCC), Porto, Portugal.
Background & Aims: Colorectal cancer (CRC) ranks second globally in cancer-related deaths and there is ongoing debate on the best populational screening strategy. This study aimed to evaluate individuals' intention to adhere to CRC screening, screening method preference, and barriers to screening.
Methods: Cross-sectional study conducted in northern Portugal, where a populational fecal occult blood test (FOBT) program is implemented.
[ACP and Ethics].
Gan To Kagaku Ryoho
December 2024
Graduate School of Health Sciences, Niigata University.
Since the 1970s, medical ethics has evolved from an informal approach to a more structured public discourse. The 4 principles proposed by Beauchamp and Childress in 1979 have gained international recognition and are useful for organizing ethical issues. However, this methodology has its limitations, and dialogue-based ethics are becoming increasingly important.
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