Highly regioselective and enantioselective asymmetric hydrogenation of cyclic dienamides catalyzed by an Rh-DuanPhos complex has been developed, which provides a readily accessible method for the synthesis of chiral cyclic allylic amines in excellent enantioselectivities (up to 99% ee). The products are valuable chiral building blocks and could be easily transformed to multisubstituted cyclohexane derivatives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol501421g | DOI Listing |
Publication Analysis
Top Keywords
synthesis chiral
8
chiral cyclic
8
cyclic allylic
8
allylic amines
8
asymmetric hydrogenation
8
highly enantioselective
4
enantioselective synthesis
4
amines rh-catalyzed
4
rh-catalyzed asymmetric
4
hydrogenation highly
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!