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| http://dx.doi.org/10.11604/pamj.2014.17.10.3798 | DOI Listing |
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Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch by inhibiting spinal oxidative stress and synaptic plasticity via SIRT1-β-catenin pathway in mice.
Redox Biol
December 2024
Department of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, 300052, China; Tianjin Research Institute of Anesthesiology, Tianjin, 300052, China. Electronic address:
Chronic itch which is primarily associated with dermatologic, systemic, or metabolic disorders is often refractory to most current antipruritic medications, thus highlighting the need for improved therapies. Oxidative damage is a novel determinant of spinal pruriceptive sensitization and synaptic plasticity. The resolution of oxidative insult by molecular hydrogen has been manifested.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Pharmacology, Central University of Punjab, Bathinda, Bathinda, Punjab, India.
Background: In previous studies, we found that quetiapine activates the AKT signaling which further inhibits the action of GSK3β. Quetiapine has been reported to possess neuroprotective potential in schizophrenia and other neurodegenerative models.
Method: On day 1 and 3, rats received bilateral intracerebroventricular (i.
Basic Science and Pathogenesis.
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December 2024
Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology & Technology, ACECR, Tehran, NY, Iran (Islamic Republic of).
Background: Alzheimer's disease (AD) is a degenerative condition characterized by a progressive decline in cognitive function, predominantly affecting older individuals. AD is associated with a range of histopathological alterations, including the gradual demise of neuronal cells, the accumulation of amyloid plaques, and the formation of neurofibrillary tangles. Furthermore, research suggests that the brain tissue of AD patients is subject to oxidative stress, which manifests as the oxidation of proteins, lipids, DNA, and the process of glycoxidation, throughout the disease progression.
View Article and Find Full Text PDFClinical Manifestations.
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IMoPA, UMR 7365, CNRS-Université de Lorraine, Nancy, France.
Background: While Alzheimer Disease (AD) patients' difficulty to recognize face identity (Werheid & Clare, 2007) has been mainly attributed to episodic and semantic memory impairments, these patients can also show abnormal difficulties at matching of unfamiliar faces for their identity, suggesting impaired perceptual function (Lavallée et al., 2016). However, since this latter evidence is based on explicit behavioural measures, the difficulties of AD patients can be due to many factors (e.
View Article and Find Full Text PDFComparative evaluation of pattern and distribution of stresses in single- and double-implant overdenture using ball-ring, positioner, and magnet-keeper attachment under different loading conditions: A finite element analysis.
J Indian Prosthodont Soc
January 2025
Department of Prosthodontics, K M Shah Dental College and Hospital, Sumandeep Vidyapeeth, Vadodara, Gujarat, India.
Aim: The aim is to evaluate and compare stress distribution characteristics of ball, magnet, and positioned attachment systems in single and double implant-retained overdentures using the finite element method (FEM).
Setting And Design: In vitro (in silico study) finite element analysis (FEA).
Materials And Methods: A Styrofoam mandible with duplicated silicon mucosa was used to construct a mandibular complete denture.
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