AI Article Synopsis
- Retinoids are compounds that include natural vitamin A and synthetic versions, known for regulating important biological processes.
- This study focused on creating a special form of retinoic acid, labeled with a carbon isotope, for tracking its effects in medical treatments.
- The newly synthesized (11)C-labeled all-trans-retinoic acid (ATRA) can help researchers visualize and compare its therapeutic effects against an artificial retinoid in treating acute promyelocytic leukemia using PET imaging.
Article Abstract
Retinoids are a class of chemical compounds which include both natural dietary vitamin A (retinol) metabolites and active synthetic analogs. Both experimental and clinical studies have revealed that retinoids regulate a wide variety of essential biological processes. In this study, we synthesized (11)C-labeled all-trans-retinoic acid (ATRA), the most potent biologically active metabolite of retinol and used in the treatment of acute promyelocytic leukemia. The synthesis of (11)C-labeled ATRA was accomplished by a combination of rapid Pd(0)-mediated C-[(11)C]methylation of the corresponding pinacol borate precursor prepared by 8 steps and hydrolysis. [(11)C]ATRA will prove useful as a PET imaging agent, particularly for elucidating the improved therapeutic activity of ATRA (natural retinoid) for acute promyelocytic leukemia by comparing with the corresponding PET probe [(11)C]Tamibarotene (artificial retinoid).
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| http://dx.doi.org/10.1016/j.bmcl.2014.05.041 | DOI Listing |
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