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Advanced Glycation End Products (AGEs) Webinar Meeting Report.
J Diabetes Sci Technol
November 2024
Diabetes Research Institute, Mills-Peninsula Medical Center, San Mateo, CA, USA.
The advanced glycation end products (AGEs) Webinar was co-hosted by Diabetes Technology Society and Kitalys Institute on August 8, 2024, with the goal of reviewing progress made in the measurement and use of AGEs in clinical practice. Meeting topics included (1) AGEs as predictors of diabetic nephropathy (DKD), (2) hemoglobin glycation index (HGI) and the glycation gap (GG), (3) formation and structure of AGEs, (4) AGEs as a risk factor of cardiovascular disease (CVD), and (5) approaches to limit or prevent AGE formation.
View Article and Find Full Text PDFThe Diabetes Technology Society Error Grid and Trend Accuracy Matrix for Glucose Monitors.
J Diabetes Sci Technol
November 2024
University of California San Francisco, San Francisco, CA, USA.
Article Synopsis
- An error grid is a tool that helps compare glucose levels measured by devices to see if they are correct and to identify any risks.
- Experts created a new error grid called the DTS Error Grid that works for both blood glucose monitors (BGMs) and continuous glucose monitors (CGMs), organizing accuracy into five risk zones.
- The results showed that the DTS Error Grid provides a clearer picture of how accurate these devices are and includes a separate matrix to evaluate how well CGMs track glucose trends over time.
A novel, centrally acting mammalian aminosterol, ENT-03, induces weight loss in obese and lean rodents.
Diabetes Obes Metab
December 2024
Enterin, Inc., Philadelphia, Pennsylvania, USA.
Article Synopsis
- ENT-03 is a newly discovered compound in newborn mice that helps regulate energy and metabolism by lowering blood glucose levels, especially in obese and diabetic mice.
- In experiments, treatment with ENT-03 led to significant weight loss and normalization of biochemical parameters following decreased food intake.
- The compound targets specific brain regions linked to appetite control and is being tested in clinical trials for potential use in treating type 2 diabetes and obesity.*
Defining an ageing-related pathology, disease or syndrome: International Consensus Statement.
Geroscience
September 2024
Cardiff School of Technologies, Cardiff Metropolitan University, Cardiff, UK.
Article Synopsis
- People are living longer globally, but longer life doesn't always mean better health as age-related diseases can greatly affect health and quality of life.
- It's important to create systems that categorize and stage these age-related issues to understand the healthcare and socioeconomic needs of aging populations.
- A recent meeting in Cardiff gathered 150 experts who agreed on three main criteria to classify age-related pathologies, which will help in addressing these health challenges effectively.
Challenges and recommendations for the translation of biomarkers of aging.
Nat Aging
October 2024
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Biomarkers of aging (BOA) are special measurements that can help scientists understand how old someone is on a biological level and how this changes with treatments.
- Recently, many new BOA have been discovered that could really help people live healthier lives as they age, but there are some problems getting these ideas into actual medical practice.
- Experts found six main challenges that are stopping BOA from being used more widely and suggested ways to make them better, such as ensuring they are easy to access and useful for everyone.
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