Ethnopharmacological Relevance: Herba Ephedra (Mahuang in Chinese), is derived from dried Ephedra sinica Stapf stems and has been widely used to treat the common cold, coughs, asthma, and edema for thousands of years. The Mahuang-Guizhi herb-pair is a famous formula composed of Mahuang and Ramulus Cinnamomi (Guizhi in Chinese, the dried twig of Cinnamomum cassia Presl.), used to improve pharmacological effects and reduce toxicity. In order to investigate the influence of Mahuang-Guizhi herb-pair ratios on bioavailability, the plasma pharmacokinetics profiles of five ephedrine alkaloids were compared following oral administration of four different ratios to rats.
Materials And Methods: Sprague-Dawley rats were randomly assigned to four groups and orally administered Mahuang-Guizhi (ratios 3:0; 3:1; 3:2; 3:4, w/w). Assays for five ephedrine alkaloids (ephedrine, pseudoephedrine, methylephedrine, norephedrine, and norpseudoephedrine) were developed and validated using ultra-high-performance liquid chromatography tandem mass spectrometry coupled with liquid-liquid extraction.
Results: Key pharmacokinetic parameters of the five ephedrine alkaloids (maximal plasma concentration, mean residence time, and half-life) were significantly different (p<0.05) after oral administration of Mahuang-Guizhi herb-pair ratios, as compared to those of Mahuang.
Conclusion: Ephedrine alkaloid pharmacokinetic differences in rat plasma could help explain previous findings of pharmacological and toxicity differences between Mahuang and Mahuang-Guizhi herb-pair preparations. These results could facilitate future studies to increase the efficacy and decrease the toxicity of Mahuang and Guizhi.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jep.2014.05.065 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification of anti-SARS-CoV-2 compounds from Qingwen Zhike prescription and exploration of their underlying mechanism by UPLC-Q-Exactive Orbitrap MS, high-throughput screening assays and transmission electron microscopy.
J Pharm Biomed Anal
December 2024
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:
Qingwen Zhike prescription (QWZK), a traditional Chinese medicine (TCM) hospital prescription developed in response to the corona virus disease 2019 (COVID-19) pandemic, has demonstrated efficacy in clinical practice. Nevertheless, its specific antiviral components and mechanisms of action remain unclear. This study screened the antiviral compounds against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from Qingwen Zhike prescription and explored the underlying mechanism through chemical composition analysis, serum and lung exposure profiles analysis, high-throughput screening, and transmission electron microscopy (TEM) observation.
View Article and Find Full Text PDFColloidal Particle in Suspensions of Maobushisaishinto Extract Granules Enhances Drug Intestinal Penetration.
Chem Pharm Bull (Tokyo)
December 2024
Faculty of Pharmacy, Kindai University.
The main ingredients of Maobushisaishinto (MBST) are ephedrine (EP), methyl eugenol (ME), and aconitine (AC). The pharmacological effects are presumed to be due to the combined effects of these ingredients. In this study, we investigated the impact of the particles present in MBST suspensions on the absorption of the ingredients.
View Article and Find Full Text PDF[Analysis of Overdose-related Posts on Social Media].
Yakugaku Zasshi
December 2024
Division of Drug Informatics, Keio University Faculty of Pharmacy.
Article Synopsis
- Intentional overdoses (OD) of OTC and prescription drugs are increasingly becoming a global issue, and there’s a lack of social media-focused research on this topic.* -
- This study analyzed over 30,000 Japanese Twitter posts related to "OD" using advanced language processing techniques, identifying specific drug mentions and emotional tones.* -
- Findings indicated a significant correlation between negative emotions and OD incidents, highlighting the potential of social media surveillance in identifying high-risk individuals and shaping prevention efforts.*
Design-assisted HPLC-UV method for therapeutic drug monitoring of pholcodine, ephedrine, and guaifenesin in biological fluids.
Sci Rep
November 2024
Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt.
Drug-drug interactions may amplify or diminish their intended effects, or even produce entirely new effects. Multicomponent mixture HPLC analysis offers a thorough and effective method for comprehending the makeup and behavior of complicated materials, advancing research and development across a range of scientific and industrial domains. A novel experimental design-assisted HPLC methodology for the concurrent investigation of the drug-drug interaction of pholcodine, ephedrine, and guaifenesin in biological fluids has been established.
View Article and Find Full Text PDFLate pleistocene exploitation of Ephedra in a funerary context in Morocco.
Sci Rep
November 2024
Research Group Tarha, Department of Historical Sciences, University of Las Palmas de Gran Canaria, Pérez del Toro 1, Las Palmas, 35003, Spain.
The active compounds found in many plants have been widely used in traditional medicine and ritual activities. However, archaeological evidence for the use of such plants, especially in the Palaeolithic period, is limited due to the poor preservation and fragility of seed, fruit, and other botanical macro-remains. In this study, we investigate the presence and possible uses of Ephedra during the Late Pleistocene based on the analysis of exceptionally preserved plant macrofossils recovered from c.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!