The surface of amastigote forms of Trypanosoma cruzi is covered by a stage-specific glycoprotein, Ssp-4. We show that Y strain-derived Ssp-4 is recognized by antibodies in sera from Chagasic patients. All 51 sera reacted with the surface of amastigotes by indirect immunofluorescence assays and immunoprecipitated Ssp-4. The human antibodies inhibited the binding of monoclonal antibodies to Ssp-4 in immunoradiometric assays, suggesting that the corresponding region of the molecule may be conserved among distinct strains of the parasite.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4269/ajtmh.1989.40.46 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Immunomodulatory activity of Trypanosoma cruzi recombinant antigen combination TSA-1-C4 and Tc24-C4 induce activation of macrophages and CD8 T cells.
Parasitol Res
January 2025
Facultad de Química, Universidad Autónoma de Yucatán (UADY), Calle 43 S/N entre calle 96 y calle 40 Colonia Inalámbrica, Mérida, Yucatán, C.P. 97069, Mexico.
Chagas disease is a chronic infection caused by the protozoan parasite, Trypanosoma cruzi, with limited benefits of the currently available anti-parasitic chemotherapeutic approaches to halt the progression of heart disease. Recombinant TSA-1-C4 and Tc24-C4 proteins have been developed as promising antigen candidates for therapeutic vaccines, leading to propose them in combination as a bivalent recombinant protein strategy. In this study, we evaluated the immunomodulatory effect of the combined TSA-1-C4 and Tc24-C4 recombinant proteins by in vitro assays using murine macrophages.
View Article and Find Full Text PDFBiological activities of lichen extracts and UHPLC-ESI-QTOF-MS analysis of their secondary metabolites.
Front Pharmacol
January 2025
Instituto de Farmacia, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile.
This research was designed to investigate the metabolite profiling, phenolics content, and the trypanocidal, nematicidal, antibacterial, antifungal, and free radical scavenging properties of Motyka. The air-dried material was extracted successively with dichloromethane and methanol (UlMeOH). Two phases were obtained from the extract with dichloromethane, one soluble in methanol (UlDCM-s) and the other insoluble (UlDCM-i).
View Article and Find Full Text PDFMolecular detection of trypanosomatids among cave-dwelling bats from Colombia.
Int J Parasitol
January 2025
Grupo de Enfermedades Infecciosas Facultad de Ciencias Pontificia Universidad Javeriana Bogotá Colombia. Electronic address:
Bats play crucial roles in various ecosystems including caves. Although the presence of trypanosomatid species in bats has been documented in Colombia, their diversity in cave-dwelling bats remains unclear. This study aimed to characterize the frequency and diversity of protists from the family Trypanosomatidae circulating in bats from the Macaregua cave ecosystem in Santander, Colombia.
View Article and Find Full Text PDFEnvironmental Challenges and Co-Infection Modulate Resistance and Tolerance Against Trypanosoma Cruzi and Trichinella Spiralis in Rats.
J Exp Zool A Ecol Integr Physiol
January 2025
Laboratorio de Ecología de Enfermedades, Instituto de Ciencias Veterinarias del Litoral (ICIVET LITORAL), Universidad Nacional del Litoral - CONICET, Santa Fe, Santa Fe, Argentina.
To overcome infection, hosts employ two defense strategies: resistance (which limits pathogen fitness), and tolerance (which reduces infection damage). These strategies may be influenced by environmental challenges such as food shortage, social conflict, and co-infections. Here, our objective was to assess defense strategies in rats infected with Trichinella spiralis and/or Trypanosoma cruzi under environmental challenges.
View Article and Find Full Text PDFSynanthropic Rodents as Bioindicator of Human Pathogens in a Tourist Area of Brazil.
Ecohealth
January 2025
Department of Agricultural and Environmental Sciences, State University of Santa Cruz, Direction of the University: Campus Soane Nazaré de Andrade, Rod. Jorge Amado, Km 16 - Salobrinho, Ilhéus, Bahia, 45662-900, Brazil.
The black rat Rattus rattus is an exotic and synanthropic rodent prominent in Brazil and with high adaptation to urban areas. The species have an omnivorous diet feed on human food resources, potentially becoming infected and spreading infectious agents that cause zoonoses such as leptospirosis, leishmaniosis, Chagas disease, and toxoplasmosis, which are significant public health concerns in the country. We analyzed the epidemiologic profile of R.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!