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When encountering severe hypoxemia that does not respond to oxygen supplementation, it is essential to consider underlying right-to-left shunting. Among various diagnostic approaches, the microbubble test via transthoracic echocardiography (TTE) is a simple, noninvasive method for detecting pulmonary arteriovenous shunts, particularly in hepatopulmonary syndrome (HPS). Although microbubbles are usually administered peripherally, using a Swan-Ganz (SG) catheter to inject microbubbles directly into the pulmonary artery may provide even more definitive diagnostic information.

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New updates on hepatopulmonary syndrome: A comprehensive review.

Respir Med

December 2024

Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Hepatopulmonary syndrome (HPS) is a serious pulmonary vascular complication that causes arterial hypoxemia in the setting of liver disease. HPS has a progressive course and is associated with a two-fold increased risk of mortality relative to cirrhotic patients without HPS. It primarily affects patients with portal hypertension.

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Article Synopsis
  • Liver transplantation is the main treatment for cirrhosis patients with hepatopulmonary syndrome (HPS), but its impact on survival rates is debated.
  • A study analyzed 181 liver transplant recipients, finding that 57.5% had HPS, with similar overall survival between HPS and non-HPS groups (around 69.8 vs 63.4 months).
  • Results showed that HPS patients experienced more post-surgery complications like delayed extubation and chest catheter insertion, but their overall survival was not negatively affected by HPS severity.
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: The prevalence of portopulmonary hypertension (PoPH) is relatively low; however, its presence significantly worsens patients' prognosis. When diagnosed, PoPH can be effectively treated, and specific therapies can lead to a substantial reduction in pulmonary circulation pressure, facilitating the safe performance of liver transplantation. Echocardiography is recommended as a first-line method for the non-invasive diagnosis of pulmonary hypertension and serves as a valuable screening tool for patients being evaluated for liver transplantation (LT).

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Background: Hepatopulmonary syndrome (HPS) is a complication in biliary atresia (BA) children following hepatoportoenterostomy. Liver transplantation (LT) was the definitive treatment of HPS. However, little was known about the risk factors between HPS and mortalities.

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