AI Article Synopsis
- A modular approach was used to create a library of constitutional isomers, leading to the discovery of six unique amphiphilic Janus dendrimers that can self-assemble into uniform onion-like vesicles.
- These vesicles, called onion-like dendrimersomes, mimic biological membranes and their size and layer count depend on the concentration of the Janus compounds in water.
- The preparation method is straightforward and requires no special equipment, making it an easy and useful tool for research and potential applications in areas like nanomedicine.
Article Abstract
A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal bilayers. These vesicles, denoted onion-like dendrimersomes, are assembled by simple injection of a solution of Janus dendrimer in a water-miscible solvent into water or buffer. These dendrimersomes provide mimics of double-bilayer and multibilayer biological membranes with dimensions and number of bilayers predicted by the Janus compound concentration in water. The simple injection method of preparation is accessible without any special equipment, generating uniform vesicles, and thus provides a promising tool for fundamental studies as well as technological applications in nanomedicine and other fields.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078827 | PMC |
| http://dx.doi.org/10.1073/pnas.1402858111 | DOI Listing |
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