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IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice.
J Allergy Clin Immunol
March 2019
Department of Allergy and Clinical Immunology, National Research Institute for Child Health & Development, Tokyo, Japan. Electronic address:
The Way We Walked with Immunology.
Annu Rev Immunol
April 2018
La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA; email:
It has been a little more than 50 years since we discovered IgE, a key molecule for the allergic response and a target for treating allergies and severe asthma. Here, I trace my career, from the kindling of my interest in immunochemistry to groundbreaking discoveries in the biology and chemistry of immunoglobulins. I describe my service to the broader community of immunologists and my role in shaping departments and research institutes.
View Article and Find Full Text PDFIdentification of IgE.
J Allergy Clin Immunol
June 2016
La Jolla Institute for Allergy & Immunology, La Jolla, Calif.
Progress in protein chemistry in the 1950s revealed that the biologic activities of proteins, such as hemoglobin and enzymes, are based on partial structures in the protein molecules. This principle suggested to us the possibility that the human antibodies responsible for induction of reaginic hypersensitivity reactions might have unique structures that are lacking in the antibody molecules involved in immunity and that the differences in the structures of human antibody molecules can be recognized by the immune systems of experimental animals. Our studies were based on the hypothesis that reaginic antibody activity is associated with a unique immunoglobulin isotype, which is now called IgE.
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