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The level of expression of thioredoxin is linked to fundamental properties and applications of wheat seeds.
Mol Plant
May 2009
National Engineering Research Centre for Wheat, Henan Agricultural University, Zhengzhou 450002, China.
Work with cereals (barley and wheat) and a legume (Medicago truncatula) has established thioredoxin h (Trx h) as a central regulatory protein of seeds. Trx h acts by reducing disulfide (S-S) groups of diverse seed proteins (storage proteins, enzymes, and enzyme inhibitors), thereby facilitating germination. Early in vitro protein studies were complemented with experiments in which barley seeds with Trx h overexpressed in the endosperm showed accelerated germination and early or enhanced expression of associated enzymes (alpha-amylase and pullulanase).
View Article and Find Full Text PDFNonmurine animal models of food allergy.
Environ Health Perspect
February 2003
Department of Pediatrics, Division of Allergy/Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA.
Article Synopsis
- Food allergies can manifest in different ways, including immediate and delayed hypersensitivity reactions and inflammation from immune complexes.
- Due to ethical concerns, animal models are employed to study food allergies—these models help understand sensitization, predict allergenicity of new proteins, and explore treatment options through immunotherapy.
- The hypothesis around IgE-mediated food allergies suggests that reactions occur when food proteins or fragments evade digestion, leading to allergen-specific IgE production in a specific immune environment.
Coca and Cooke on the classification of hypersensitiveness.
J Allergy Clin Immunol
January 2003
National Institute of Allergy and Infectious Diseases, History of Medicine Division, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
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