AI Article Synopsis
- A new series of compounds called 6-allylthio-3-aralkylthio-4,5-dimethylpyridazines and 1-allylthio-4-alkylthio-5,6,7,8-tetrahydrophthalazine were created to find new anticancer drugs.
- The synthesis process included multiple steps like creating specific rings and adding chemical groups to enhance their properties.
- Some of the new compounds displayed strong antiproliferative effects against breast cancer and liver cancer cells, with five being more effective than the standard chemotherapy drug 5-FU, particularly compound 6f, which showed the most promise.
Article Abstract
A new series of 6-allylthio-3-aralkylthio-4,5-dimethylpyridazines 5a-5k and 1-allylthio-4-alkylthio-5,6,7,8-tetrahydrophthalazine 6a-6j was synthesized from maleic anhydride derivatives for development of new anticancer agents. The process involves the formation of pyridazine and phthalazine rings, dichlorination, allylthiolation, and aralkylthiolation. These new compounds showed antiproliferative activities against breast cancer (MCF-7) and hepatocarcinoma (Hep3B) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 21 synthesized compounds, five compounds (5a, 5b, 6b, 6d, and 6f) showed higher potency than 5-FU for inhibiting the growth of cell line. The results indicated that compound 6f had the highest activity towards MCF-7 and Hep3B cells. These results suggest the potential anticancer activity of compounds 5a, 5b, 6b, 6d, and 6f.
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| http://dx.doi.org/10.1007/s12272-014-0416-3 | DOI Listing |
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