Three rats pressed a lever for food on differential-reinforcement-of-low-rate (DRL) schedules ranging from 16 s to 96 s. During DRL performance, a response to a second lever turned off chamber illumination and produced a timeout period during which food could not be obtained. During timeout periods, a response to the second lever reinstated the DRL schedule and associated chamber illumination. The percentage of session time spent in timeout periods increased as the DRL schedule was lengthened and decreased when the schedule was shortened. Changes in timeout percentage were primarily due to changes in the mean time per timeout rather than to changes in the rate of initiation of timeout periods. Extinction increased the timeout percentage. Elimination of the timeout contingency decreased the response rate to the timeout lever, but did not systematically affect DRL lever pressing. The rate of reinforcement appeared to be a primary determinant of the percent of session time spent in timeout periods.
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http://dx.doi.org/10.1016/0376-6357(92)90044-E | DOI Listing |
Neurobiol Learn Mem
January 2025
School of Psychology, University of New South Wales, Australia. Electronic address:
Humans and animals use information about future access to rewards to influence their behaviour in the present, however the evidence for this is largely anecdotal. Here we use the nicotine intravenous self-administration paradigm to ask whether rats can use an auditory stimulus signalling a long (450 s) signalled time-out on the next trial to influence their nicotine intake in the present. Rats were trained to choose between low (15 µg/kg/infusion), medium (30 µg/kg/infusion) or high (60 µg/kg/infusion) doses of nicotine on any given trial.
View Article and Find Full Text PDFJ Bone Joint Surg Am
December 2024
Jack Hughston Memorial Hospital, Phenix City, Alabama.
Background: Operative fires are rare but unforgettable events, with the potential for devastating outcomes. It is estimated that 650 operating room (OR) fires occur each year in the United States, with the use of electrocautery devices and polymethylmethacrylate (PMMA) as the primary ignition and fuel sources. There are several case reports of OR fires caused by PMMA and electrocautery in the literature, but, to our knowledge, no formal studies have been performed exposing the flammability of PMMA and how PMMA reacts to an electrocautery ignition source.
View Article and Find Full Text PDFActa Neurochir (Wien)
November 2024
Pacific Neuroscience Institute, Providence Saint John's Health Center, 2125 Arizona Ave, Santa Monica, CA, 90404, USA.
Objective: Carotid artery injury is a rare, but major complication of endonasal operations. The morbidity and mortality of such a complication can be mitigated by preparedness and a clear plan set in place to address the hemorrhage expeditiously. This study examines the implementation of such a carotid injury timeout checklist and demonstrates its effectiveness in a patient with possible arterial injury.
View Article and Find Full Text PDFSpine Deform
October 2024
Department of Neurosurgery, Hartford HealthCare and Quinnipiac University Frank H. Netter School of Medicine, Westport, CT, USA.
Purpose: Spine deformity surgery is a complex multi-step procedure that has a relatively high complication rate. The use of surgical safety checklists has been shown to reduce perioperative adverse events, but existing lists are varied and non-specific for spinal deformity surgery. Thus, the purpose of this study was to develop a comprehensive surgical checklist for complex spinal corrective surgery.
View Article and Find Full Text PDFPalliat Med
December 2024
Department of Primary and Community Care, Radboudumc, Nijmegen, The Netherlands.
Background: Implementing shared decision-making in oncology practice is often limited, particularly integrating the patient's context into decision-making. To improve this, we conducted a quality improvement project, attempts to accomplish this by: (1) Integrating the patient's context into shared decision-making during consultation with the medical oncologist; (2) Actively involving the GP and case manager (a specialized oncology nurse), who often have knowledge about the patient's context, and; (3) Giving the person with advanced cancer a time-out period of up to 2 weeks to consider and discuss treatment options with others, including close family and friends.
Aim: To explore how persons with advanced cancer and their involved professionals experienced shared decision-making after the introduction of .
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