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Unlabelled: Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Clemastine fumarate, the over-the-counter antihistamine and muscarinic receptor blocker, has remyelinating potential in MS. A clemastine arm was added to an ongoing platform clinical trial TRAP-MS ( NCT03109288 ) to identify a cerebrospinal fluid (CSF) remyelination signature and to collect safety data on clemastine in patients progressing independently of relapse activity (PIRA).
View Article and Find Full Text PDFContraception Update: A Focus on Safety and Efficacy.
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This clinical update serves as a brief summary of recently published and potentially practice changing journal articles. We review recent publications related to contraceptive safety and efficacy. The article discusses updated medical eligibility recommendations, effectiveness of progestin-only pills (including the newly approved over-the-counter pill), safety of estrogen containing contraceptives in those with migraine, topiramate interactions with hormonal contraception, and the use of nonsteroidal antiinflammatory drugs (NSAIDs) with oral emergency contraception to improve efficacy.
View Article and Find Full Text PDFSt. John's Wort Extract Ze 117 and Escitalopram Alter Plasma and Hippocampal Lipidome in a Rat Model of Chronic-Stress-Induced Depression.
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Medical Department, Max Zeller Soehne AG, Seeblickstrasse 4, 8590 Romanshorn, Switzerland.
Chronic stress is a key factor in the development of depression. It leads to hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, which in turn increases the formation of glucocorticoids (GCs). Chronically elevated GC levels disrupt neuroplasticity and affect brain lipid metabolism, which may, ultimately, contribute to the development of depression.
View Article and Find Full Text PDFUnlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.
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Transgressive Acts: Michel Foucault's Lessons on Resistance for Nurses.
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Bloomberg Faculty of Nursing, Centre for Critical Qualitative Health Research, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
In this paper, we bring together Foucault's biography and oeuvre to explore key concepts that support the analysis of nurses' acts of resistance. Foucault reflected on the power relations taking place in health services, making his contribution especially useful for the analysis of resistance in this context. Over three decades, he proposed a nonnormative philosophy while concomitantly engaging in transgressive practices guided by values such as human rights and social justice.
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