This study presents a hybrid Q-switched Nd:LuVO₄ laser with an acousto-optic modulator (AOM) and a Cr⁴⁺:YAG saturable absorber. The importance of the modulation frequency of the AOM in this dual-loss modulation system is examined with two distinct observations: (1) the periodic-ramp pulse characteristics with the modulation frequency, and (2) the existence of the intrinsic modulation frequency for minimizing the pulsewidth. The shortest pulsewidth and the highest peak power were 10.6 ns and 13.9 kW, respectively, at a pump power of 10 W. Compared with the passively Q-switched laser, which has a pulsewidth of 18.3 ns, the ratio of pulse compression reaches 42%. Finally, numerical simulations based on the rate equations are used to verify the experimental results.
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http://dx.doi.org/10.1364/AO.53.003459 | DOI Listing |
Sci Rep
December 2024
Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Breast cancer is a leading cause of cancer-related deaths among women globally. It is imperative to explore novel biomarkers to predict breast cancer treatment response as well as progression. Here, we collected six breast cancer samples and paired normal tissues for high-throughput sequencing.
View Article and Find Full Text PDFSci Rep
December 2024
Cardiopulmonary Physiotherapy Laboratory, Physical Therapy Department, Universidade Federal de São Carlos, Rodovia Washington Luiz, São Carlos, SP, 13565-905, Brazil.
This study investigated the impact of mild COVID-19 on HRV in groups stratified by time after infection and to compare to a healthy group of the same age without previous virus infection and without need of hospitalization. This is a cross-sectional study. We divided the sample into four groups: control group (CG) (n = 31), group 1 (G1): ≤6 weeks (n = 34), group 2 (G2): 2-6 months (n = 30), group 3 (G3): 7-12 months (n = 35) after infection.
View Article and Find Full Text PDFJ Nutr
December 2024
Bioactive Compounds and Carbohydrates (BIOCARB) Research Group - Department of Food Science and Technology, Universidade Federal de Viçosa, Avenida Peter Henry Rolfs, s/n, Viçosa, MG, 36570-900, Brazil. Electronic address:
Background: Kombucha, a fermented beverage obtained from a Symbiotic Culture of Bacteria and Yeast (SCOBY), has shown potential in modulating gut microbiota, although no clinical trials have been done.
Objective: We aimed to evaluate the effects of regular black tea kombucha consumption on intestinal health in individuals with and without obesity.
Methods: A pre-post clinical intervention study was conducted lasting eight weeks.
J Affect Disord
December 2024
Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada. Electronic address:
Background: Abnormalities in effort-based decision-making have been consistently reported in major depressive disorder (MDD). Evidence indicates that metabolic factors, such as insulin resistance and dyslipidemia, which are highly prevalent in MDD, are independently associated with reward disturbances. Herein, we investigate the moderating effect of metabolic factors on effort-based decision-making in individuals with MDD.
View Article and Find Full Text PDFClin Gastroenterol Hepatol
December 2024
Division of Gastroenterology, Department of Medicine, University of California San Diego, La Jolla, California, USA; Division of Biomedical Informatics, Department of Medicine, University of California San Diego, La Jolla, California, USA. Electronic address:
Background And Aims: We sought to ascertain how prior exposure to TNF antagonists impacts treatment response with various classes of advanced therapies in patients with ulcerative colitis (UC), through a systematic review and meta-analysis.
Methods: Through a systematic review of multiple databases through June 30, 2024, we identified 17 RCTs in 8871 adults with moderate-severe UC who were treated with different advanced therapies vs. placebo, and reported efficacy in induction of clinical remission, stratified by prior exposure to TNF antagonists.
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