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In-situ restructuring of Ni-based metal organic frameworks for photocatalytic CO hydrogenation.
Nat Commun
January 2025
Department of Chemistry, University of Toronto, Toronto, ON, Canada.
As the global quest for sustainable energy keeps rising, exploring novel efficient and practical photocatalysts remains a research and industrial urge. Particularly, metal organic frameworks were proven to contribute to various stages of the carbon cycle, from CO capture to its conversion. Herein, we report the photo-methanation activity of three isostructural, nickel-based metal organic frameworks incorporating additional niobium, iron, and aluminum sites, having demonstrated exceptional CO capture abilities from thin air in previous reports.
View Article and Find Full Text PDFRecent advancements in the quest of benzazoles as anti-Mycobacterium tuberculosis agents.
Bioorg Chem
February 2025
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, Punjab 160 062, India; School of Chemical Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata, West Bengal 700 032, India. Electronic address:
Tuberculosis (TB) remains a global health challenge, claiming numerous lives each year, despite recent advancements in drug discovery and treatment strategies. Current TB treatment typically involves long-duration chemotherapy regimens that are often accompanied by adverse effects. The introduction of new anti-TB drugs, such as Bedaquiline, Delamanid, and Pretomanid, offers hope for more effective treatment, although challenges persist keeping the quest to find new anti-TB chemotypes an incessant exercise of medicinal chemists.
View Article and Find Full Text PDFComparative analysis of ethical standards for the utilization of Assisted Reproductive Technologies in Brazil: Resolutions from 1992 to 2023.
JBRA Assist Reprod
December 2024
Christus University Center (Unichristus), Fortaleza, CE, Brazil.
Due to its documented records and technological achievements, in vitro embryo creation technology is still honored worldwide forty years after Louise Brown's birth on July 25, 1978. The World Health Organization (WHO) reports that one in six people globally who are of reproductive age may have infertility at some point in their lives. In this environment, it has become noteworthy for couples or patients to want to become pregnant through operations carried out by Assisted Human Reproduction Centers (AHRCs).
View Article and Find Full Text PDFThe ClinGen Syndromic Disorders Gene Curation Expert Panel: Assessing the Clinical Validity of 111 Gene-Disease Relationships.
medRxiv
November 2024
Translational Research, Illumina Inc., Cambridge, Cambridgeshire, United Kingdom.
Purpose: The Clinical Genome Resource (ClinGen) Gene Curation Expert Panels (GCEPs) have historically focused on specific organ systems or phenotypes; thus, the ClinGen Syndromic Disorders GCEP (SD-GCEP) was formed to address an unmet need.
Methods: The SD-GCEP applied ClinGen's framework to evaluate the clinical validity of genes associated with rare syndromic disorders. 111 Gene-Disease Relationships (GDRs) associated with 100 genes spanning the clinical spectrum of syndromic disorders were curated.
Bacterial Hybrid Light-Emitting Diodes.
Adv Mater
November 2024
Technical University of Munich, TUM Campus Straubing for Biotechnology and Sustainability, Chair of Biogenic Functional Materials, Schulgasse, 22, 94315, Straubing, Germany.
Photon down-converting filters with fluorescent proteins (FPs) are a new frontier in the quest for rare-earth-free and non-toxic color filters for white light-emitting diodes. There are, however, concerns related to the FP purification costs and lack of FP recyclability/reuse. Here, the direct use of bacteria in photon down-converting filters can be of utmost relevance, eliminating purification and allowing in situ production of new FPs.
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