Background: IncobotulinumtoxinA (INCO) was approved for aesthetic use in the United States in 2011. When reconstituted per manufacturer's instructions, diminished delivery of INCO in US may result.
Objective: Investigators sought to determine whether potential loss of decreased motor activity could be demonstrated, using a simple reconstitution technique.
Methods And Materials: In this 5-patient study, investigators added 2.0 mL of saline to INCO powder at the bottom of the first of 5 vials, swirling gently to dissolve INCO powder at the bottom. Reconstituted INCO was discarded and the cap was replaced. The "empty" vial then received 0.6 mL of saline, and was swirled and inverted 3 times to ensure dissolution. The 0.6 mL from the first vial was added to the second "empty" vial and the process was repeated for the remaining 3 vials (5 vials per patient). Patients were injected from reconstitution of "empty" vials to determine neuromodulatory activity. Pre- and post-treatment patient photographs of maximal contraction were taken.
Results: Markedly diminished maximal frown could be observed in all 5 patients.
Conclusion: Improper reconstitution of INCO, or swirling without inversion of the vial following saline injection, can result in significant loss of units of the neurotoxin in the clinical setting.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Novel high-pressure/high-temperature reactor cell for in situ and operando x-ray absorption spectroscopy studies of heterogeneous catalysts at synchrotron facilities.
Rev Sci Instrum
May 2024
Institut de Chimie Moléculaire de Grenoble, UAR2607 CNRS- Université Grenoble Alpes, Grenoble F-38000, France.
This paper presents the development of a novel high-pressure/high-temperature reactor cell dedicated to the characterization of catalysts using synchrotron x-ray absorption spectroscopy under operando conditions. The design of the vitreous carbon reactor allows its use as a plug-flow reactor, monitoring catalyst samples in a powder form with a continuous gas flow at high-temperature (up to 1000 °C) and under high pressure (up to 1000 bar) conditions, depending on the gas environment. The high-pressure/high-temperature reactor cell incorporates an automated gas distribution system and offers the capability to operate in both transmission and fluorescence detection modes.
View Article and Find Full Text PDFLong-term stability of reconstituted incobotulinumtoxinA: how can we reduce costs of botulinum toxin therapy?
J Neural Transm (Vienna)
October 2017
Toxogen, Hannover, Germany.
Botulinum neurotoxin (BNT), the biologically active component of botulinum toxin (BT), is a large double-stranded protein susceptible to various physical and chemical influences. All BT type A (BT-A) drugs are stored as powders allowing shelf lives from 24 to 36 months. After reconstitution, the specified shelf life is reduced to 8-24 h.
View Article and Find Full Text PDFIncorrect reconstitution of incobotulinumtoxinA leads to loss of neurotoxin.
J Drugs Dermatol
June 2014
Background: IncobotulinumtoxinA (INCO) was approved for aesthetic use in the United States in 2011. When reconstituted per manufacturer's instructions, diminished delivery of INCO in US may result.
Objective: Investigators sought to determine whether potential loss of decreased motor activity could be demonstrated, using a simple reconstitution technique.
Potential for mass production of nickel-based nanomaterials by carbonyl process.
J Nanosci Nanotechnol
August 2008
Vale Inco Limited, Mississauga, Ontario, Canada L5K 1Z9.
High purity micron and sub-micron scale nickel materials have been mass-produced by the nickel carbonyl process for many decades. The same technology is being explored for mass production of nano-scale nickel products. The paper presents an overview of nickel carbonyl technology suitable for mass production of nano-scale nickel powders with surface areas exceeding 100 m2/g, and various three-dimensional nickel based micro structures.
View Article and Find Full Text PDFRb6(InCo)2(Si9O26): a mixed-metal silicate containing 20-membered-ring silicate single layers with a very low Si:O ratio.
Inorg Chem
March 2006
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 300, Republic of China.
A new cobalt-indium silicate, Rb6(InCo)2(Si9O26), has been synthesized via a high-temperature, high-pressure hydrothermal method and characterized by single-crystal X-ray diffraction. It crystallizes in the noncentrosymmetric orthorhombic space group Aba2 (No. 41) with a = 20.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!