Injury of the thoracic aorta following a major blunt trauma to the chest occurs most frequently at the aortic isthmus and more than 80% of such patients die within 1st 30 minutes. However, less than 5% of patients survive and later develop chronic thoracic aortic aneurysm (TAA). Usually, most cases of chronic traumatic TAA have no symptoms for a long time after an accident. We report a case of successful repair for a chronic traumatic TAA 16 years after a jet skiing crash. A 37-year-old woman complained of left chest pain, back pain, and cough. A computed tomography showed a descending TAA, which was 5 cm in a maximum diameter. The final diagnosis was chronic traumatic TAA. Thoracic endovascular aortic repair (TEVAR) or graft replacement was considered as an operative procedure. We performed graft replacement to avoid complications of TEVAR, considering her small external iliac arteries.
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JBJS Case Connect
January 2025
Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.
Case: A 16-year-old woman presented with acute on chronic knee pain and instability following a twisting injury. The tibial insertion of the anterior cruciate ligament (ACL) was nonvisualized on magnetic resonance imaging. A cord-like ACL, originating from the lateral intercondylar notch and inserting smoothly into the anterior horn of the intact lateral meniscus, was found on arthroscopy.
View Article and Find Full Text PDFG3 (Bethesda)
January 2025
Department of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
The conserved MAP3K DLKs are widely known for their functions in synapse formation, axonal regeneration and degeneration, and neuronal survival, notably under traumatic injury and chronic disease conditions. In contrast, their roles in other neuronal compartments are much less explored. Through an unbiased forward genetic screening in C.
View Article and Find Full Text PDFCancer Sci
January 2025
Department of Traumatic Orthopedics, Shenzhen Longhua District Central Hospital, Shenzhen, Guangdong, China.
The development of mesothelin (MSLN) epitope reactive T cells is observed in mice that are immunized with the MSLN vaccine. Engineered T cells expressing MSLN-reactive high-affinity TCR exhibit extraordinary therapeutic effects for invasive pancreatic ductal adenocarcinoma in a mouse model. However, the generation of MSLN-reactive T cells through the introduction of MSLN-deficient thymus and the transplantation of the latter as a cure for cancer treatment have not been tested to date.
View Article and Find Full Text PDFEur J Trauma Emerg Surg
January 2025
Department of Orthopedic, Trauma and Reconstructive Surgery, Percy Military Hospital, 101 Avenue Henri Barbusse, Clamart, 92140, France.
Introduction: Targeted muscle reinnervation (TMR) is a technique that has proven effective for the treatment and prevention of chronic pain following amputation, though its adoption remains limited. The authors report on their initial experience using TMR.
Methods: A prospective study was conducted in a military trauma center involving traumatic amputees treated with either curative or preemptive TMR.
Clin Orthop Relat Res
January 2025
Department of Rehabilitation, Radboud University Medical Center, Nijmegen, the Netherlands.
Background: Many patients with a lower limb socket-suspended prothesis experience socket-related problems, such as pain, chronic skin conditions, and mechanical problems, and as a result, health-related quality of life (HRQoL) is often negatively affected. A bone-anchored prosthesis can overcome these problems and improve HRQoL, but these prostheses have potential downsides as well. A valid and reliable tool to assess potential candidates for surgery concerning a favorable risk-benefit ratio between potential complications related to bone-anchored prostheses and improvements in HRQoL is not available yet.
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