AI Article Synopsis
- Bleeding complications in dengue can occur even if there is no plasma leakage present.
- The study compared plasma levels of factors affecting blood vessel permeability in three types of dengue cases: those with bleeding but no plasma leakage, dengue hemorrhagic fever, and non-complicated dengue.
- Findings showed that in patients without plasma leakage, levels of VEGF-A and its receptors did not link to bleeding incidents, supporting the idea that bleeding complications can happen independently of changes in blood vessel barriers.
Article Abstract
Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.
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| http://dx.doi.org/10.3855/jidc.4542 | DOI Listing |
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