AI Article Synopsis
- The study aimed to evaluate lymph node status after neoadjuvant chemoradiotherapy in rectal cancer patients using a new scoring system that considers fibrosis and residual tumor presence.
- A retrospective cohort of 202 rectal cancer patients who received chemoradiotherapy and surgery was analyzed to see how the new scoring system affected their survival and recurrence rates.
- Findings showed that a lower lymph node regression score significantly indicated a better survival outcome and was associated with a higher recurrence rate, suggesting that the scoring system is a useful prognostic tool.
Article Abstract
Aim: The primary aim of this study was to examine lymph node status after neoadjuvant chemoradiotherapy (CRT) using a novel scoring system describing the pathological lymph node regression grade. The proposed scoring system was based on the percentage of fibrosis and the presence of residual tumour amount. The secondary aim of the study was to assess the oncological impact of this scoring system.
Method: The project was a retrospective cohort study over a 10-year period. Two hundred and two patients with rectal cancer who had received CRT followed by curative surgery were included. A histopathologist prospectively scored each specimen and the impact of the scoring system on survival and recurrence was analysed.
Results: One hundred and ninety patients completed long-course preoperative CRT and formed the basis of the study. Overall, 40 recurrences (local and distant) were observed over a median follow-up of 36 months. The lymph node regression score was a significant predictor of tumour recurrence (hazard ratio 1.273, 95% CI 1.048-1.548; P = 0.015). The overall mortality rate was 21%, and a lower lymph node regression score was correlated with an improved survival curve (P = 0.01).
Conclusion: The results demonstrate that lymph node response to neoadjuvant CRT based on a nodal regression scoring system is related to recurrence.
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| http://dx.doi.org/10.1111/codi.12682 | DOI Listing |
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