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Chemical conditioning approach to post-treat temperature-phased anaerobic digestate to improve resource recovery, odour reduction and biosolids quality.
Environ Technol
January 2025
Department of Chemistry and Biology, Toronto Metropolitan University, Toronto, Canada.
Biosolids has several challenges, such as its high water content, huge volume, odour, and pathogen presence. Regulations require biosolids to be reused and disposed of safely. Polymer conditioning focuses on volume reduction, leaving pathogen and odour reduction unaddressed.
View Article and Find Full Text PDFPharmacokinetics and safety of bictegravir in pregnant and postpartum persons with HIV and their infants.
J Acquir Immune Defic Syndr
November 2024
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.
Background: Limited data exist on bictegravir pharmacokinetics in pregnancy among persons with HIV (PWH) and infant washout.
Setting: Nonrandomized, open-label, multi-center phase-IV prospective study of bictegravir pharmacokinetics and safety in pregnant PWH and their infants.
Methods: Steady-state 24-hour pharmacokinetic sampling of oral bictegravir 50 mg once daily (a component of fixed-dose combination bictegravir/emtricitabine/tenofovir alafenamide) during the 2nd and 3rd trimesters and postpartum was performed.
Neurotensin receptor agonist PD149163 modulates LPS-induced enterocyte apoptosis by downregulating TNFR pathway and executioner caspase 3 in endotoxemic mice: insights from in vivo and in silico study.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Zoology, University of Allahabad, Senate House, University Road, Old Katra, Prayagraj, Uttar Pradesh, 211002, India.
This study was designed to evaluate the dose-dependent efficacy of neurotensin receptor-1 (NTSR1) agonist PD149163 in the amelioration of the lipopolysaccharide (LPS)-induced apoptosis in the gastrointestinal tract (GIT) of mice. PD149163 is an analogue of NTS, a GIT tri-decapeptide with anti-inflammatory and anti-oxidative effects. Swiss-albino mice (female/8 weeks/25 ± 2.
View Article and Find Full Text PDFClinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis.
Clin Pharmacokinet
January 2025
Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Background And Objective: Psilocybin is currently being extensively studied as a potential therapeutic agent for multiple psychiatric disorders. Here, a systematic literature review of all published pharmacokinetic data on the pharmacologically active metabolite of psilocybin, psilocin, is presented.
Methods: The review includes clinical studies that reported pharmacokinetic data and/or parameters after psilocybin administration in humans.
Role of syringic acid in enhancing growth, photosynthesis, and antioxidant defense in lettuce exposed to arsenic stress.
Physiol Plant
January 2025
Department of Molecular Biology and Genetics, Faculty of Science, Necmettin Erbakan University, Meram, Konya, TURKEY.
Heavy metal pollution, especially arsenic toxicity, significantly impairs plant growth and development. Phenolic acids, known for their antioxidant properties and involvement in stress signaling, are gaining increased attention as plant secondary metabolites with the potential to enhance plant resistance to these stressors. This study aimed to investigate the effects of different concentrations of syringic acid (SA1, 10 μM; SA2, 250 μM; SA3, 500 μM) on growth, photosynthetic parameters, and antioxidant activity in lettuce seedlings subjected to arsenic stress (As, 100 μM).
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