An overview of the state of the art in the extraction, isolation, and analytical determination of bioactive compounds in peppers of the genus Capsicum is presented. The review is structured by classes of phytochemicals. Both major and minor constituents of peppers are considered. Modern trends in analytical chemistry of nutrients in regard to pepper analysis with particular focus on chromatographic and related methods are discussed. Attention was paid to controversial questions of pepper analysis, including but not limited to problems of sample degradation and the completeness of extraction of target analytes. The rationale for choosing an optimal strategy of analysis is given.
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http://dx.doi.org/10.1080/10408398.2011.652316 | DOI Listing |
Curr Microbiol
January 2025
Department of Microbiology and Botany, School of Sciences, J. C. Road, JAIN (Deemed-to-be University), Bangalore, Karnataka, 560027, India.
Endophytic fungi are non-pathogenic organisms that colonise healthy plant tissues asymptomatically. Endophytes derived from medicinal plants are sources for identifying natural products and bioactive compounds with potential uses for industry, medicine, agriculture, and related sectors. In the present study, ethyl acetate crude extracts of four endophytic fungal isolates (CALF1, CALF4, and CASF1) from the medicinal plant Plectranthus amboinicus showed potent antimicrobial activity against the test pathogenic bacteria Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis using disc diffusion assays.
View Article and Find Full Text PDFMed Chem
January 2025
Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune 70000, Morocco.
Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2). This activation, triggered by ataxia-telangiectasia mutated (ATM) kinase, leads to dopaminergic neuron loss and α-synuclein aggregation, a critical pathophysiological aspect of Parkinson's disease (PD). To halt PD progression, pharmacological inhibition of c-Abl kinase is essential.
View Article and Find Full Text PDFAnticancer Agents Med Chem
January 2025
Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Unlabelled: Mesenchymal‒epithelial transition factor (c-Met), a receptortyrosine kinase (RTK), plays a vital role in cell proliferation, migration and invasion, and tumour metastasis.
Objective: With increasing duration of treatment, many tumours gradually develop drug resistance. Therefore, novel antitumour drugs need to be developed to treat patients with tumours.
J Agric Food Chem
January 2025
Laboratory of Bioactives (LABBIO), Food and Nutrition Graduate Program (PPGAN), Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 22290-240, Brazil.
Phenolic compounds (PC) were analyzed by UHPLC-ESI-QTOF-MS in two sorghum genotypes, harvested in two growing seasons (GS) at five distinct days after flowering (DAF) to evaluate how genotype/GS influences the PC synthesis and antioxidant capacity during grain growth. Total phenolic contents were strongly correlated with antioxidant capacity ( > 0.9, < 0.
View Article and Find Full Text PDFHeliyon
January 2025
Pharmacy Program, Gandaki University, Pokhara, 33700, Nepal.
Lapsi ( (Roxb.) B.L.
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