Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/jama.2014.132 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An study of FIKK9.5 protein of for identification of therapeutics.
J Biomol Struct Dyn
December 2024
School of Biotechnology, KIIT Deemed To be University, Bhubaneswar, Odisha, India.
The FIKK protein family, encompassing 21 serine-threonine protein kinases, is a distinctive cluster exclusive to the Apicomplexa phylum. Predominantly located in which is a malarial parasite, with a solitary gene identified in a distinct apicomplexan species, this family derives its nomenclature from - phenylalanine, isoleucine, lysine, lysine (FIKK), a conserved amino acid motif. Integral to the parasite's life cycle and consequential to malaria pathogenesis, the absence of orthologous proteins in eukaryotic organisms designates it as a promising antimalarial drug target.
View Article and Find Full Text PDFConvergent Synthesis, Kinetics, and Computational Studies of Indole(Phenyl)Triazole Bi-Heterocycles Modified With Propanamides as Elastase Inhibitors.
Chem Biodivers
November 2024
Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Chungnam, South Korea.
Biological screening combined with the synthesis of heterocyclic compounds with numerous functions is the most effective approach available for pharmacological assessment of potential future medications. In the under taken research that is presented here, 4-(1H-indol-3-yl)butanoic acid was sequentially converted into 4-(1H-indol-3-yl)butanoate, 4-(1H-indol-3-yl)butanohydrazide, and 5-[3-(1H-indol-3-yl)propyl]-1,2,4-triazole-2-thiol as a nucleophile. By treating aryl amines with 3-bromopropanoyl chloride in a series of parallel reactions, different electrophiles were created, leading to the formation of N-(aryl)-3-bromopropanamides.
View Article and Find Full Text PDFTargetoid hemosiderotic hemangioma: A review article.
Semin Diagn Pathol
November 2024
University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, United States. Electronic address:
Article Synopsis
- Targetoid hemosiderotic hemangioma (THH) is a rare vascular lesion that mainly affects adults, usually developing after trauma, with no significant gender preference.
- The review analyzes THH's characteristics, differentiating it from similar conditions like Kaposi's sarcoma and retiform hemangioendothelioma.
- Clinically, THH appears as painless lesions with a distinctive target-like look; histologically, it shows specific vascular features and can be identified with immunohistochemical markers.
Clinicopathological analysis of sclerosing haemangiomatoid nodular transformation of the spleen: analysis of three cases and a literature review.
World J Surg Oncol
November 2024
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, P.R. China.
Objective: To examine the clinicopathological features, immunohistochemical profiles, and differential diagnosis of sclerosing angiomatiod nodular transformation (SANT).
Methods: Three cases of SANT of the spleen, diagnosed between 2014 and 2023 at the Affiliated Hospital of Zunyi Medical University, were analysed. Pathological features were assessed using haematoxylin and eosin staining, followed by immunohistochemistry with the EnVision system.
Laser Excision of Buccal Mucosal Growth: A Case Report.
Cureus
September 2024
Periodontics and Implantology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
The mucosal tissues are prone to overgrowths as hyperplasia or hypertrophy, which present a spectrum of clinical challenges. These lesions are located at different sites and differ in size and pathology related to their origin. They present as solitary nodules of pink or red on the tongue, gingiva, buccal mucosa and other oral tissues.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!