AI Article Synopsis
- Researchers isolated the flavanone sakuranetin from Baccharis retusa twigs, identifying it as the active antimicrobial component through various spectroscopic techniques (NMR and MS).
- The structure of a new form of sakuranetin was confirmed using X-ray diffractometry.
- Sakuranetin displayed significant antifungal activity against multiple pathogenic yeast species, with minimum inhibitory concentrations ranging from 0.32 to 0.63 μg/μL, suggesting its potential for developing new antifungal treatments.
Article Abstract
Bioactivity-guided fractionation of an antimicrobial active extract from twigs of Baccharis retusa C. DC. (Asteraceae) yielded the flavanone 5,4'-dihydroxy-7-methoxy-flavanone (sakuranetin) as responsible for the detected activity. The structure of the bioactive compound was established on the basis of spectroscopic data analysis, including NMR and MS. Additionally, the structure of a new crystal form of sakuranetin was confirmed by X-ray diffratometry. The minimum inhibitory concentrations (MIC) of isolated compound were determined against pathogenic yeast belonging to the genus Candida (six species), Cryptococcus (two species/four serotypes) and S. cerevisiae BY 4742 (S288c background) and ranged from 0.32 to 0.63 μg/μL. Our results showed that sakuranetin, which structure was fully characterized, could be used as a tool for the design of novel and more efficacious antifungal agents.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271719 | PMC |
| http://dx.doi.org/10.3390/molecules19067528 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway.
Acta Pharmacol Sin
January 2017
Jiangsu Key Laboratory of Drug Screening, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
Recent studies focus on promoting neurite outgrowth to remodel the central nervous network after brain injury. Currently, however, there are few drugs treating brain diseases in the clinic by enhancing neurite outgrowth. In this study, we established an NGF-induced PC12 differentiation model to screen novel compounds that have the potential to induce neuronal differentiation, and further characterized 4,10-Aromadendranediol (ARDD) isolated from the dried twigs of the Baccharis gaudichaudiana plant, which exhibited the capability of promoting neurite outgrowth in neuronal cells in vitro.
View Article and Find Full Text PDFSakuranetin reverses vascular peribronchial and lung parenchyma remodeling in a murine model of chronic allergic pulmonary inflammation.
Acta Histochem
July 2016
Department of Bioscience, Federal University of Sao Paulo, Santos, SP, Brazil.
Background And Purpose: Asthma is a disease of high prevalence and morbidity that generates high costs in hospitalization and treatment. Although the airway is involved in the physiopathology of asthma, there is also evidence of the importance of vascular and lung parenchyma inflammation and remodeling, which can contribute to the functional pulmonary alterations observed in asthmatic patients. Our aim was to evaluate treatment using sakuranetin, a flavone isolated from the twigs of Baccharis retusa (Asteraceae), on vascular and lung parenchyma alterations in an experimental murine model of asthma.
View Article and Find Full Text PDFStructural crystalline characterization of sakuranetin--an antimicrobial flavanone from twigs of Baccharis retusa (Asteraceae).
Molecules
June 2014
Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, 09972-270 Diadema-SP, Brazil.
Article Synopsis
- Researchers isolated the flavanone sakuranetin from Baccharis retusa twigs, identifying it as the active antimicrobial component through various spectroscopic techniques (NMR and MS).
- The structure of a new form of sakuranetin was confirmed using X-ray diffractometry.
- Sakuranetin displayed significant antifungal activity against multiple pathogenic yeast species, with minimum inhibitory concentrations ranging from 0.32 to 0.63 μg/μL, suggesting its potential for developing new antifungal treatments.
Gaudichanolides A and B, clerodane diterpenes from Baccharis gaudichaudiana.
J Nat Prod
July 2005
Department of Biochemistry, Okayama University of Science, 1-1 Ridai-cho, Okayama City, 700-0005 Japan.
Two new clerodane diterpenoids, gaudichanolides A (1) and B (2), were isolated from the dried twigs of Baccharis gaudichaudiana, together with 7-oxo-16,19-dihydroxy-3,4-dehydroclerodan-15,20-diacid dilactone, spathulenol, 4,10-aromadendranediol, kobusone, trans-cosanyl ferulate, and defuscin. The structures and relative stereochemistry of 1 and 2 were elucidated by detailed 2D NMR spectroscopic experiments, and the absolute stereochemistry of 1 was determined by X-ray crystallographic analysis.
View Article and Find Full Text PDFT-2 toxin and diacetoxyscirpenol metabolism by Baccharis spp.
Appl Environ Microbiol
September 1988
Department of Plant Pathology, University of Minnesota, St. Paul 55108.
Hybrids resulting from crosses between Baccharis sarothroides and B. pilularis (FS1), B. sarothroides (FS2) and B.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!