Diastereoselective autoxidation allowed preparation of new tricyclic endoperoxides. These compounds and their methylated analogs were evaluated against the in vitro growth of Plasmodium falciparum, the malaria-causing parasite, showing moderate activities. However, hybrid molecules composed of the tricyclic peroxide moiety and 7-chloro-4-aminoquinoline were synthesized and displayed a marked increase in antiplasmodial activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c4ob00787e | DOI Listing |
Publication Analysis
Top Keywords
tricyclic endoperoxides
8
design synthesis
4
synthesis evaluation
4
evaluation tricyclic
4
endoperoxides potential
4
potential antiplasmodial
4
antiplasmodial agents
4
agents diastereoselective
4
diastereoselective autoxidation
4
autoxidation allowed
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!