AI Article Synopsis
- Sinonasal intestinal-type adenocarcinomas (ITACs) are aggressive cancers similar to colorectal adenocarcinomas, and their prognostic factors are poorly understood, particularly regarding the MET signaling pathway.
- In a study of 72 ITAC cases, it was found that 64% had elevated MET protein levels, while 52% exhibited chromosome 7 polysomy, indicating potential alterations in MET signaling.
- The presence of certain histological features and incomplete tumor resection correlated with worse patient outcomes, pointing to the significance of MET in the development of ITACs.
Article Abstract
Background: Sinonasal intestinal-type adenocarcinomas (ITACs) have a poor prognosis, and are defined on the basis of their morphological similarities to colorectal adenocarcinomas. MET signaling pathway is involved in oncogenesis in various cancers. Nothing is currently known about the role of MET in ITACs.
Methods: In a series of 72 ITACs, we investigated MET protein levels by immunohistochemistry (IHC) and gene copy number by in situ hybridization. These findings were analyzed as a function of clinical data, histological typing, and patient outcome.
Results: MET protein was overproduced in 64% of cases and chromosome 7 polysomy was observed in 52% of cases. No tumor displayed MET amplification. The presence of mucinous or solid histological components, T3/T4 tumors, and incomplete resection were associated with a poor outcome.
Conclusion: MET is overproduced in about two third of ITACs, suggesting a role for the MET signaling pathway in the oncogenesis of these tumors.
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| http://dx.doi.org/10.1002/hed.23795 | DOI Listing |
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