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| http://dx.doi.org/10.1002/hep.27253 | DOI Listing |
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Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment.
Hepatology
August 2015
Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Article Synopsis
- Clinical evidence suggests that serious drug-induced liver injuries may be caused by the adaptive immune system reacting to drug-protein complexes, a condition known as drug-induced allergic hepatitis, though specific animal models have been lacking.
- In a study with female Balb/cJ mice, researchers observed liver damage and immune cell infiltration after exposure to halothane, indicating that immune tolerance in the liver can be disrupted.
- The findings point to potential mechanisms for drug-induced allergic hepatitis that could help develop animal models for further research and suggest that a breakdown in liver tolerance might make individuals more susceptible to this condition.
Hepatotoxicity of halogenated inhalational anesthetics.
Iran Red Crescent Med J
September 2014
Department of Molecular Hepatology, Middle East Liver Disease Center, Tehran, IR Iran ; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Article Synopsis
- * A review of 52 studies from 1966 to 2013 confirmed that all halogenated anesthetics, like halothane and enflurane, can cause liver damage, particularly through a metabolic pathway involving cytochrome P-450 2E1, while sevoflurane appears to have a lower risk.
- * Although liver toxicity from these anesthetics is not common, it is essential to acknowledge the potential link, especially with older agents like halothane compared to newer ones with lower hepatotoxicity.
Halothane-induced hepatitis: paradigm or paradox for drug-induced liver injury.
Hepatology
November 2014
Department of Chemistry, University of California at Davis, Davis, CA.
Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice.
Hepatology
November 2014
Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD.
Unlabelled: Liver eosinophilia has been associated with incidences of drug-induced liver injury (DILI) for more than 50 years, although its role in this disease has remained largely unknown. In this regard, it was recently shown that eosinophils played a pathogenic role in a mouse model of halothane-induced liver injury (HILI). However, the signaling events that drove hepatic expression of eosinophil-associated chemokines, eotaxins, eosinophil infiltration, and subsequent HILI were unclear.
View Article and Find Full Text PDFHalothane: how should it be used in a developing country?
East Mediterr Health J
February 2012
Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The anaesthetic agent halothane is still widely used in developing countries including the Islamic Republic of Iran because of its low price. Because of halothane-induced hepatitis, a rare complication, it has been replaced by other inhalation anaesthetics in Western countries; it has been suggested by some Iranian professionals that the Islamic Republic of Iran should do the same. We evaluated various dimensions of this replacement through a literature review to assess the incidence of halothane-induced hepatitis and costs of anaesthetics in the country.
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