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Effect of erythropoietin on free radical oxidation and glycoprotein expression in platelets under conditions of chronic renal failure. | LitMetric
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Effect of erythropoietin on free radical oxidation and glycoprotein expression in platelets under conditions of chronic renal failure.

M V Osikov

Bull Exp Biol Med

Department of Phatological Phisiology, Chelyabinsk State Medical Academy, Ministry of Health of the Russian Federation, Chelyabinsk, Russia,

Published: May 2014

A short-term open prospective study examined 62 patients at the terminal stage of chronic renal failure. The experimental group received erythropoietin in a total dose of about 40,000 U. The expression of glycoproteins IIb-IIIa, IIb, and Ib was enhanced, the content of LPO products was elevated, and SOD and catalase activities were reduced in platelets from patients with chronic renal failure. Administration of erythropoietin partially restored free radical oxidation and expression of glycoproteins IIb-IIIa, IIb, and Ib in platelets. A significant correlation was revealed between the expression of platelet receptors on the one hand, and content of LPO products and SOD and catalase activities, on the other hand.

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http://dx.doi.org/10.1007/s10517-014-2483-3DOI Listing

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