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In vitro ultrastructure and biodegradation of activated plasma albumin gel derived from human samples: A prospective observational study.
Clin Adv Periodontics
December 2024
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Background: In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative.
View Article and Find Full Text PDFThe space of transport coefficients allowed by causality.
Nat Phys
October 2024
Mathematical Sciences and STAG Research Centre, University of Southampton, Highfield, Southampton UK.
As an effective theory, relativistic hydrodynamics is fixed by symmetries up to a set of transport coefficients. A lot of effort has been devoted to explicit calculations of these coefficients. Here we adopt a more general approach, deploying bootstrap techniques to rule out theories that are inconsistent with microscopic causality.
View Article and Find Full Text PDFUnraveling GPCRs Allosteric Modulation. Cannabinoid 1 Receptor as a Case Study.
Proteins
November 2024
Department of Chemistry, University of Southern California, Los Angeles, California, USA.
G-protein-coupled receptors (GPCRs) constitute one of the most prominent families of integral membrane receptor proteins that mediate most transmembrane signaling processes. Malfunction of these signal transduction processes is one of the underlying causes of many human pathologies (Parkinson's, Huntington's, heart diseases, etc), provoking that GPCRs are the largest family of druggable proteins. However, these receptors have been targeted traditionally by orthosteric ligands, which usually causes side effects due to the simultaneous targeting of homologous receptor subtypes.
View Article and Find Full Text PDFAfrican origin haplotype protective for Alzheimer's disease in ε4 carriers: exploring potential mechanisms.
bioRxiv
October 2024
John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.
Article Synopsis
- ε4 is the most significant genetic risk factor for Alzheimer's disease (AD), with about half of AD patients having at least one ε4 allele.
- Researchers found that the African-specific A allele of rs10423769 significantly reduces the AD risk associated with ε4 homozygotes by roughly 75%.
- The protective variant is located in a specific region of chromosome 19, demonstrating differences at the structural and DNA methylation levels compared to non-protective variants, and emphasizing the need for diverse ancestry representation in AD studies.
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