AI Article Synopsis
- The release of neurotransmitters at presynaptic nerve terminals is essential for synaptic transmission and happens at specialized areas called active zones.
- The process involves complex interactions between various molecular machines that operate on a core macromolecular scaffold at these active zones, though their exact composition is still not fully understood.
- This review discusses the importance of active zones in neurotransmitter release and recent advances in neuroproteomic methods that help identify the key proteins involved in these processes.
Article Abstract
The release of neurotransmitters from synaptic vesicles exocytosing at presynaptic nerve terminals is a critical event in the initiation of synaptic transmission. This event occurs at specialized sites known as active zones. The task of faithfully executing various steps in the process is undertaken by careful orchestration of overlapping sets of molecular nano-machineries upon a core macromolecular scaffold situated at active zones. However, their composition remains incompletely elucidated. This review provides an overview of the role of the active zone in mediating neurotransmitter release and summarizes the recent progress using neuroproteomic approaches to decipher their composition. Key proteins of these nano-machineries are highlighted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11113288 | PMC |
| http://dx.doi.org/10.1007/s00018-014-1657-5 | DOI Listing |
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