The XXI World Congress of Psychiatric Genetics (WCPG), sponsored by the International Society of Psychiatric Genetics (ISPG), took place in Boston, Massachusetts, on 17-21 October 2013. Approximately 900 participants gathered to discuss the latest findings in this rapidly advancing field. The following report was written by student travel awardees. Each was assigned one or more sessions as a rapporteur. This manuscript represents topics covered in most, but not all of the oral presentations during the conference, and contains some of the major notable new findings reported.
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http://dx.doi.org/10.1097/YPG.0000000000000043 | DOI Listing |
Eur J Epidemiol
January 2025
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, 800 E. Leigh St., Suite 100, Richmond, VA, 23298, USA.
Cigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: The IDEAL study is a randomized clinical trial investigating the psychosocial, behavioral, and cognitive impacts of genetic risk disclosure for late-onset Alzheimer's disease (LOAD) among Latinos.
Methods: We used address-based sampling in northern Manhattan to recruit Latinos aged 40-64 for a community-based survey and clinical trial. Data collection encompasses demographics, Alzheimer's disease (AD) family history, knowledge and beliefs about AD and genetics, current mental health status, acculturation, impact of COVID-19, familism, fatalism, caregiver status, and prior AD genetic testing.
Alzheimers Dement
December 2024
South Texas Alzheimer's Disease Research Center, Harlingen, TX, USA.
Background: High blood pressure (BP) level and variability has been linked to stroke, cerebral small vessel disease (CSVD), cognitive decline, and dementia. However, it is unclear whether sex/gender influences the association of BP level and variability with CSVD. Therefore, we aimed to examine sex-differences in the association of CSVD with 24-h BP level and variability.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
South Texas Alzheimer's Disease Research Center, Harlingen, TX, USA.
Background: Cognitive impairment is associated with mortality. However, evidence using population-based studies is scarce, is limited to one cognitive assessment, and lacks the inclusion of non-fatal adverse health outcomes. Therefore, we aimed this study to (i) investigate the association of cognitive function with mortality and cardiovascular risk and (ii) determine whether cognitive tests improve the risk-stratification of endpoints beyond conventional risk factors.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The University of Texas Rio Grande Valley School of Medicine, Harlingen, TX, USA.
Background: The increasing number of natural disasters and wars will result in complex emergencies affecting how individuals age. Additionally, the continued complex crises in certain areas of the globe exacerbates risks for chronic health conditions and poverty. Implementing ethical and community-engaged research in these complex humanitarian settings requires tailored approaches.
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