Background & Aims: Information delineating the possible causes for elevated serum aminotransferase activity among persons with chronic hepatitis B virus (HBV) infection is limited.
Methods: We analysed data collected from a population-based cohort of persons with chronic HBV infection followed from 2001 to 2010 to determine the frequency and causes of elevated aminotransferase activity. Any elevation concurrent with an HBV DNA level ⩾2000 IU/ml was attributed to immune active hepatitis B. Participant medical charts were reviewed by expert clinical staff to determine the presence of additional or alternative attributable causes. For each participant, a serum aminotransferase elevation could be attributed to more than one cause.
Results: Among 1090 persons with chronic HBV infection, the mean follow-up was 7.7 years and the median age in 2001 was 39 (range 19-96) years; 634 (58.2%) had ⩾1 elevated aminotransferase level during follow-up and 438 (69.1%) of persons with ⩾1 elevation had at least one cause assigned for the elevation. The most common causes of aminotransferase elevations were immune active hepatitis B (48.4%), alcohol consumption (30.8%), and non-alcoholic fatty liver disease (NAFLD) (24.7%). Among participants with HBV DNA levels persistently less than 2000 IU/ml, the most common causes were NAFLD or alcohol consumption.
Conclusions: In this population-based cohort of persons with chronic HBV infection, the prevalence of elevated aminotransferase activity was high and attributable to immune active chronic hepatitis B in approximately half of the cases; however, NAFLD or alcohol consumption were also common causes for enzyme elevations. These findings underscore the importance of monitoring HBV DNA levels, in addition to aminotransferase activity, among persons with chronic HBV infection so that appropriate interventions, including antiviral therapy, are utilised.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jhep.2014.05.045 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Digital Home-Based Self-Monitoring System for People with Heart Failure: Protocol for Development of SmartHeart and Evaluation of Feasibility and Acceptability.
JMIR Res Protoc
January 2025
School of Exercise and Nutrition Sciences, Institute for Physical Activity and Nutrition, Deakin University, Burwood, Australia.
Background: Heart failure (HF) is a chronic, progressive condition where the heart cannot pump enough blood to meet the body's needs. In addition to the daily challenges that HF poses, acute exacerbations can lead to costly hospitalizations and increased mortality. High health care costs and the burden of HF have led to the emerging application of new technologies to support people living with HF to stay well while living in the community.
View Article and Find Full Text PDFMarkers for Pressure Injury Risk in Individuals with Chronic Spinal Cord Injury: A Pilot Study.
Adv Skin Wound Care
January 2025
At University of Texas Southwestern Medical Center, Dallas, Texas, United States, Yi-Ting Tzen, PhD, is Assistant Professor, Department of Applied Clinical Research, Department of Physical Medicine and Rehabilitation, and Department of Orthopaedic Surgery; Wei-Han Tan, MD, is Assistant Professor, VA North Texas Health Care System, Dallas, and Department of Physical Medicine and Rehabilitation; Patricia T. Champagne, PhD, is Postdoctoral Fellow, Department of Applied Clinical Research and Department of Physical Medicine and Rehabilitation; Jijia Wang, PhD, is Assistant Professor, Department of Applied Clinical Research; and Merrine Klakeel, DO, is Assistant Professor, Department of Physical Medicine and Rehabilitation. Kath M. Bogie, DPhil, is Professor, Department of Orthopaedics, Case Western Reserve University, Cleveland, Ohio, United States, and VA Northeast Ohio Healthcare System, Cleveland. Timothy J. Koh, PhD, is Professor, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Illinois, United States.
Objective: To identify markers associated with pressure injury (PrI) history in individuals with spinal cord injury (SCI) using two approaches: skin blood flow (SBF) response toward localized heating, and serum marker for insulin resistance.
Methods: For this cross-sectional, observational study of adults with chronic traumatic SCI at T12 and above, researchers recruited two groups of participants: with history of PrI (group 1), and without history of PrI (group 2). The study protocol included obtaining fasting blood samples and measurement of SBF at bilateral heels with localized heating of 42 °C for 30 minutes from all participants.
The liminal space between hope and grief: The phenomenon of uncertainty as experienced by people living with relapsing-remitting multiple sclerosis.
PLoS One
January 2025
Department of Care Ethics, University of Humanistic Studies, Utrecht, The Netherlands.
Background: People with the chronic disease Multiple Sclerosis are subjected to different degrees of profound uncertainty. Uncertainty has been linked to adverse psychological effects such as feelings of heightened vulnerability, avoidance of decision-making, fear, worry, anxiety disorders, and even depression. Research into Multiple Sclerosis has a predominant focus on the scientific, practical, and psychosocial issues of uncertainty.
View Article and Find Full Text PDFObjective: Aim: The aim is to investigate the causes of stress and its impact on women's mental and physical health indicators.
Patients And Methods: Materials and Methods: The research was conducted from 2022 to 2024 and involved 157 women from Zhytomyr oblast (Ukraine) of different ages, education, professions, and geographic residence. The research methods included analysis of literary sources, medical and sociological (survey), statistical method.
Objective: Aim: To improve the results of treatment of patients with chronic wounds of the lower extremities by using complex treatment, including surgical interventions, VAC- therapy, as well as studying the effect of negative pressure on bacterial films of wounds, based on microbiological examination and immune-histochemical data.
Patients And Methods: Materials and Methods: During the period from 2019 to 2023 at the department's clinic, 68 patients with chronic wounds of the lower extremities were examined and treated. These are mainly women (n=63) aged from 35 to 80 years.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!