Hesperadin, an established human Aurora B inhibitor, was tested against cultures of and and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity relationships for each parasite. In this study, we identified multiple non-toxic compounds with high potency against and with good selectivity. These compounds may represent an opportunity for continued optimization.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045489 | PMC |
| http://dx.doi.org/10.1039/C4MD00045E | DOI Listing |
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