Rift Valley fever (RVF) is a mosquito-borne zoonotic disease characterized by a high rate of abortion in ruminants, and febrile illness, hemorrhagic fever, retinitis and encephalitis in humans. RVF is caused by the RVF virus (RVFV), belonging to the genus of the family . RVFV encodes a major virulence factor, , which is dispensable for viral replication, yet required for evasion of host innate immune responses. RVFV inhibits host gene upregulation at the transcriptional level, while promoting viral translation in the cytoplasm. In this article, we summarize the virology and pathology of RVF, and countermeasure development for RVF, with emphasis on function and applications.
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| http://dx.doi.org/10.2217/fvl.13.117 | DOI Listing |
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