The authors describe rabdomyosarcoma of different location in two patients of different age. One patient, 51 years old, had rabdomyosarcoma located in the larynx. Its detection was late because its late manifestation. The patient refused the suggested treatment and the issue was lethal within the first year after the first symptoms had been discovered. The second patient was a child, aged 5, with rabdomyosarcoma on the upper lip. The tumour was detected relatively early and it was cured (operatively, by radiation and chemio-therapy). Unfortunately the result was lethal two years after the beginning of the illness.
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Curr Opin Pediatr
February 2025
Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, Maryland, USA.
Purpose Of Review: With growing emphasis on data-driven research in pediatric oncology, particularly in the context of advances in molecular characterization and precision medicine, there is an urgent need for comprehensive data-sharing initiatives. This review explores how the Childhood Cancer Data Initiative (CCDI) addresses this critical need.
Recent Findings: CCDI plays a key role in enhancing pediatric cancer research by improving data integration, sharing, and collaboration.
J Immunother Cancer
November 2024
Department of Bone Marrow Transplantation & Cellular Therapy, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
Background: Oncofetal splice variants of extracellular matrix (ECM) proteins present a unique group of target antigens for the immunotherapy of pediatric cancers. However, limited data is available if these splice variants can be targeted with T cells expressing chimeric antigen receptors (CARs).
Methods: To determine the expression of the oncofetal version of tenascin C (TNC) encoding the C domain (C.
J Cancer Res Ther
July 2024
Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Objective: The current treatment of pediatric non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) is a multimodal risk-based approach. Today, smaller fields and lower doses of radiotherapy (RT) have become standard. In this study, it was aimed to evaluate the treatment outcomes and toxicity profile in children with NRSTS that received RT as a part of multimodal therapy.
View Article and Find Full Text PDFJ Vet Diagn Invest
January 2025
Veterinary Medical Diagnostic Laboratory, Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
An 8-y-old National Show Horse mare was presented for evaluation of pneumonia and laminitis. Harsh bronchovesicular sounds were auscultated throughout both lung fields, and the mare had signs of moderately painful laminitis. Thoracic ultrasonography revealed lung consolidation throughout the dorsal aspect of both lungs, and radiography revealed an extensive diffuse-to-patchy bronchointerstitial lung pattern.
View Article and Find Full Text PDFInt J Surg Pathol
September 2024
Department of Pathology, King George's Medical University, Lucknow, India.
Sarcomas of thyroid glands represent a distinctive subset of rare and perplexing anomaly that present a challenges in the field of thyroid pathology. Thyroid sarcomas, primary or secondary, are exceptionally rare with only a handful of case reports documented so far. The challenges lie in the fact that certain primary thyroid malignancies of epithelial origin may exhibit spindle cell morphology, making them difficult to differentiate from thyroid sarcomas.
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