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Large Language Model-Based Critical Care Big Data Deployment and Extraction: Descriptive Analysis.
JMIR Med Inform
March 2025
Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, No.119 Nansihuanxi Road, Fengtai District, Beijing, 100070, China, 86 17611757717.
Background: Publicly accessible critical care-related databases contain enormous clinical data, but their utilization often requires advanced programming skills. The growing complexity of large databases and unstructured data presents challenges for clinicians who need programming or data analysis expertise to utilize these systems directly.
Objective: This study aims to simplify critical care-related database deployment and extraction via large language models.
Animal models of post-acute COVID-19 syndrome: a call for longitudinal animal studies.
Front Immunol
March 2025
Department of Public Laboratory, The Third People's Hospital of Kunming City/Infectious Disease Clinical Medical Center of Yunnan Province, Kunming, Yunnan, China.
Animal models are indispensable for unraveling the mechanisms underlying post-acute sequelae of COVID-19 (PASC). This review evaluates recent research on PASC-related perturbations in animal models, drawing comparisons with clinical findings. Despite the limited number of studies on post-COVID conditions, particularly those extending beyond three months, these studies provide valuable insights.
View Article and Find Full Text PDFDevelopment of a tertiary lymphoid structure-based prognostic model for breast cancer: integrating single-cell sequencing and machine learning to enhance patient outcomes.
Front Immunol
March 2025
Research Laboratory Center, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
Background: Breast cancer, a highly prevalent global cancer, poses significant challenges, especially in advanced stages. Prognostic models are crucial to enhance patient outcomes. Tertiary lymphoid structures (TLS) within the tumor microenvironment have been associated with better prognostic outcomes.
View Article and Find Full Text PDFARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.
Front Immunol
March 2025
Semmelweis University, Department of Physiology, Budapest, Hungary.
Objective: Contact hypersensitivity (CHS), or allergic contact dermatitis (ACD), is an inflammatory skin disorder characterized by an exaggerated allergic reaction to specific haptens. During this delayed-type allergic reaction, the first contact with the allergen initiates the sensitization phase, forming memory T cells. Upon repeated contact with the hapten, the elicitation phase develops, activating mostly macrophages, cytotoxic T cells, and neutrophilic granulocytes.
View Article and Find Full Text PDFNatural products for the treatment of ulcerative colitis: focus on the JAK/STAT pathway.
Front Immunol
March 2025
Department of Gastroenterology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China.
Ulcerative colitis (UC) is an autoimmune disease with an incompletely understood pathogenesis. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway plays a key role in immune response and inflammation. More and more studies demonstrated that JAK/STAT signaling pathway is associated with the pathogenesis of UC.
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