Background: To investigate events possibly related to the development of D-galactose induced senescence, we examined whether 8-iso PGF(2α) formation, a marker of in vivo lipid peroxidation is altered and whether its biosynthesis is associated with 11-dehydro-TXB(2) excretion rate, as a marker of in vivo platelet activation. In this setting, we also investigated the relationship between proinflammatory mediators (IL-6 and TNF-α from one, and lipid peroxidation and platelet activation, from another aspect.
Methods And Results: Forty animals were divided, depending on treatment with d-galactose into: placebo and D-galactose treated rats. 8-iso-PGF(2α), IL-6 and TNF-α were measured in plasma, while 11-dehydro-TXB(2) was determined in the urine after a six week treatment with d-galactose. Compared to placebo, d-galactose treated animals showed significantly higher levels of all measured parameters.
Conclusions: D-galactose induced changes in the rate of F(2)-isoprostane formation are associated with the changes in the excretion rate of 11-dehydro-TXB(2).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cyto.2014.05.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
YBX1 alleviates ferroptosis in osteoporosis via the ATF4/FSP1 axis in an mC manner.
J Orthop Surg Res
January 2025
Kunshan First People's Hospital Joint Surgery Department, 566 Qianjin East Road, Kunshan City, Suzhou, Jiangsu Province, 215399, China.
Background: Interactions between RNA-binding proteins and RNA regulate RNA transcription during osteoporosis. Ferroptosis, a programmed cell death caused by iron metabolism, plays a vital role in osteoporosis. However, the mechanisms by which RNA-binding proteins are involved in ferroptosis during osteoporosis remain unclear.
View Article and Find Full Text PDFBitter acids from Humulus lupulus L. alleviate D-galactose induced osteoblastic senescence and bone loss via regulating AKT/mTOR-mediated autophagy.
J Food Drug Anal
December 2024
School of Pharmacy, Naval Medical University, Shanghai, 200433, China.
Bitter acids (BA) are main component of Humulus lupulus L. (hops). They are known for beer brewing and have various biological and pharmacological properties, especially the bone-protective effect confirmed by our previous in vivo study.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand.
Background: Our previous studies reported that D-galactose (D-gal) administration for four to eight weeks caused metabolic disturbance, brain mitochondrial dysfunction, and brain aging, leading to cognitive dysfunction in similar with natural aging condition. Spermidine is a polyamine that can be found naturally. Spermidine has been showed the beneficial effects on various models, such as attenuating metabolic/gut impairments in obesity, and ameliorating memory loss in aged model.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Zoology, University of Lucknow, Lucknow, India.
Background: Various investigations have elucidated the impact of diet and environmental toxins on the aging process. Melamine (Mel) is a widely recognized and infamous food adulterant with documented toxicity in various organs, including the brain. Nevertheless, there is currently a dearth of reports on the neurotoxic effects of Mel in aging neurons.
View Article and Find Full Text PDFUltrasound-assisted ionic liquid extraction of polysaccharides from Crataegus songarica K. Koch fruits: Structural characterization and Antioxidant Activity.
Chem Biodivers
January 2025
Yili Normal University, School of Chemisty and Chemical Engineering, 448 Jiefang West Road, Yining City, Xinjiang, 835000, Yining, CHINA.
Article Synopsis
- The study focuses on optimizing an ultrasound-assisted ionic liquid extraction (UAILE) method to extract polysaccharides from Crataegus songarica fruits, achieving a 34.37% yield under specific conditions.
- The optimal extraction settings include an ultrasonic power of 400 W, a temperature of 79 °C, and a relatively high liquid-solid ratio, making it more effective than traditional extraction methods.
- The extracted polysaccharides, characterized as a heteropolysaccharide with notable antioxidant properties, could have potential applications in the food and pharmaceutical industries.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!