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Zhizichi decoction alleviates depressive-like behaviors through modulating mitochondria-associated membrane via the IP3R3-GRP75-VDAC1 complex.
J Ethnopharmacol
March 2025
School of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:
Ethnopharmacological Relevance: Zhizichi Decoction (ZZCD), a traditional Chinese medicine (TCM), is derived from the combination of Gardenia jasminoides J.Ellis [Rubiaceae] and Semen Sojae Praeparatum, a fermented derivative of Glycine max (L.) Merr.
View Article and Find Full Text PDFExploration of scientific connotation of "Yin-Jing" medical properties of Cyathula Officinalis via potentiating therapeutic effect, guidance and targetability.
J Ethnopharmacol
March 2025
Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, 24 Heping Road, Harbin 150040, China. Electronic address:
Unlabelled: ETHNIC PHARMACOLOGICAL RELEVANCE: "Cyathula officinalis Kuan (COK)" has the effect of "guiding the drug downward" and can enhance the efficacy of formula, e.g., Shentong Zhuyu Decoction (STZYD).
View Article and Find Full Text PDFEvaluating quality consistency of Celosiae Cristatae Flos by four dimensional fingerprints combined with antioxidant activity.
Spectrochim Acta A Mol Biomol Spectrosc
March 2025
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China. Electronic address:
Celosiae Cristatae Flos (CCF) has haemostatic and anti-dysentery properties, making it a natural medicine worthy of further development. However, there are few studies on it and most of them are based on high performance liquid chromatography. Consequently, there is a need to develop a comprehensive quality evaluation method based on multiple analytical techniques to reveal the composition of CCF.
View Article and Find Full Text PDFEstablishment and application of a rapid method for the determination of both total and unbound anlotinib concentrations by high-performance liquid chromatography-tandem mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
March 2025
Department of Pharmacy, Chongqing University Cancer Hospital, No.181 Hanyu Road, Shapingba District, Chongqing 400030, PR China. Electronic address:
The unbound concentration of anlotinib is closely associated with its therapeutic efficacy and adverse reactions. In this study, we established an accurate and rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the detection of total and unbound concentrations of anlotinib, which was subsequently applied to clinical samples. The separation of unbound and protein-bound anlotinib was achieved through filtration-ultrafiltration (CF-UF).
View Article and Find Full Text PDFN-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer.
J Pharm Biomed Anal
March 2025
Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, Brazil. Electronic address:
A luminescence-based method was developed to detect gentamicin using silver nanoparticles (AgNPs) associated with nitrogen-doped graphene quantum dots (N-GQDs). When gentamicin sulfate interacts with the AgNPs/N-GQDs system, the characteristic blue fluorescence of N-GQDs, which had been previously turned off by AgNPs, is restored. Under specific conditions (such as the amount of synthesis dispersion and pH), this AgNPs/N-GQDs probe enabled quantification of gentamicin ranging from 3.
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