Compact counterpulsation (CP) is a novel external counterpulsation system. The preoperative clinical utility of compact CP therapy in patients has not been established. In the present report, we describe a case wherein compact CP therapy was successfully used to treat severe ischemic heart failure. A 70-year-old man was diagnosed with ischemic heart disease and mitral valve regurgitation at 61 years of age. Therefore, he underwent coronary artery bypass and mitral valve plasty. The patient's condition started to gradually deteriorate at 68 years of age, and he became progressively dependent on catecholamine support. Mitral valve regurgitation recurred, which caused worsening of heart function. Before a mitral valve replacement, the patient had been treated with compact CP therapy to improve heart function and general condition. The patient's clinical condition improved with compact CP therapy after only ten sessions; in addition, he could be weaned off catecholamine support. No adverse effects were observed, and therefore, he could complete the CP therapy as an outpatient. Mitral valve replacement was performed after a total of 44 sessions. The patient had an uneventful postoperative course and was discharged on the 18th postoperative day. Compact CP therapy was thus performed on our patient without any discomfort and appears to be an effective treatment for patients with severe ischemic heart failure.
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http://dx.doi.org/10.1007/s10047-014-0772-2 | DOI Listing |
Cancer Cell
December 2024
Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA. Electronic address:
Molecular subtypes, such as defined by The Cancer Genome Atlas (TCGA), delineate a cancer's underlying biology, bringing hope to inform a patient's prognosis and treatment plan. However, most approaches used in the discovery of subtypes are not suitable for assigning subtype labels to new cancer specimens from other studies or clinical trials. Here, we address this barrier by applying five different machine learning approaches to multi-omic data from 8,791 TCGA tumor samples comprising 106 subtypes from 26 different cancer cohorts to build models based upon small numbers of features that can classify new samples into previously defined TCGA molecular subtypes-a step toward molecular subtype application in the clinic.
View Article and Find Full Text PDFNat Commun
January 2025
iHuman Institute, ShanghaiTech University, Shanghai, China.
The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer during activation remains poorly understood. In this study, we present the structures of the APJR dimer and monomer complexed with its endogenous ligand apelin-13.
View Article and Find Full Text PDFJMIR Cancer
January 2025
Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, Netherlands.
Background: Survivorship care plans (SCPs), ie, personalized health care plans for cancer survivors, can be used to support the growing group of melanoma survivors throughout their disease trajectory. However, implementation and effectiveness of SCPs are suboptimal and could benefit from the involvement of stakeholders in developing a user-centered design.
Objective: The aim of this study was to identify the ideal SCP for patients with melanoma in terms of functions and features to be included according to different stakeholders and to explore their underlying motives.
Nat Commun
December 2024
Department of Advanced Manufacturing and Robotics, College of Engineering, Peking University, Beijing, China.
Prosthetic knees represent a prevalent solution for above-knee amputation rehabilitation. However, satisfying the ambulation requirements of users while achieving their comfort needs in terms of lightweight, bionic, shock-absorbing, and user-centric, remains out of reach. Soft materials seem to provide alternative solutions as their properties are conducive to the comfort aspect.
View Article and Find Full Text PDFNat Commun
December 2024
Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, USA.
Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases. Here, we present the minimal versatile genetic perturbation technology (mvGPT), a flexible toolkit designed for simultaneous and orthogonal gene editing, activation, and repression in human cells. The mvGPT combines an engineered compact prime editor (PE), a fusion activator MS2-p65-HSF1 (MPH), and a drive-and-process multiplex array that produces RNAs tailored to different types of genetic perturbation.
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