AI Article Synopsis
- Researchers created biocompatible and biodegradable polyurethanes (PUs) using castor oil and polypropylene glycols, incorporating various carbohydrate crosslinkers like glucose, sucrose, starch, and cellulose.
- The mechanical and thermal properties of these PUs were analyzed via SEM, revealing that the type of polyol used had a greater impact on glass transition temperature and sorption behavior than the crosslinker type.
- All synthesized PUs showed biodegradability and were non-cytotoxic to normal lung cells, suggesting that carbohydrates can enhance the properties of PUs for biomedical device applications.
Article Abstract
Biocompatible and biodegradable polyurethanes (PUs) based on castor oil and polypropylene glycols (PPGs) were prepared using various carbohydrate crosslinkers: monosaccharide (glucose), disaccharide (sucrose) and polysaccharides (starch and cellulose). The mechanical and thermal properties were investigated and interpreted on the basis of SEM study. The advantage of incorporating various carbohydrates is to have tunable mechanical properties and biodegradability due to variety in their structure. The glass transition temperature and sorption behavior were dominated by the type of polyol than by the type of crosslinker. All the PUs were observed to be biodegradable as well as non-cytotoxic as revealed by MTT assay in normal lung cell line L132. The study supports the suitability of carbohydrates as important components of biocompatible PUs for development of biomedical devices.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.carbpol.2014.04.021 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predicting purification process fit of monoclonal antibodies using machine learning.
MAbs
December 2025
Department of Purification, Microbiology and Virology, Genentech Inc, South San Francisco, CA, USA.
In early-stage development of therapeutic monoclonal antibodies, assessment of the viability and ease of their purification typically requires extensive experimentation. However, the work required for upstream protein expression and downstream purification development often conflicts with timeline pressures and material constraints, limiting the number of molecules and process conditions that can reasonably be assessed. Recently, high-throughput batch-binding screen data along with improved molecular descriptors have enabled development of robust quantitative structure-property relationship (QSPR) models that predict monoclonal antibody chromatographic binding behavior from the amino acid sequence.
View Article and Find Full Text PDFPrecise Manipulation on the Structural Defects of Poly (Triazine Imide) Single Crystals for Efficient Photocatalytic Overall Water Splitting.
Angew Chem Int Ed Engl
January 2025
Fuzhou University, Chemistry, 523 Gongye Rd, Gulou, 350000, Fuzhou, CHINA.
Conjugated polymers, represented by polymeric carbon nitrides (PCNs), have risen to prominence as new-generation photocatalysts for overall water splitting (OWS). Despite considerable efforts, achieving highly crystalline PCNs with minimal structural defects remains a great challenge, and it is also difficult to examine the exact impact of complex defect states on OWS process, which largely limits their quantum efficiency. Herein, we devise a 'in-situ salt flux' assisted copolymerization protocol by using nitrogen-rich and nitrogen-deficient monomers to precisely manipulate the structural defects of poly (triazine imide) (PTI) single crystals.
View Article and Find Full Text PDFMetal-organic frameworks generated from oligomeric ligands with functionalized tethers.
Chem Sci
December 2024
Department of Chemistry and Biochemistry, University of California, San Diego La Jolla California 92093 USA
Metal-organic frameworks (MOFs) can be prepared from oligomeric organic ligands to prepare materials referred to as oligoMOFs. Studies of oligoMOFs are relatively limited, with most existing reports focused on fundamental structure-property relationships. In this report, functional groups, such as terminal alkynes and pyridine groups, are installed on the tether between 1,4-benzene dicarboxylic acid (Hbdc) groups of the dimer ligands.
View Article and Find Full Text PDFHydrogen Bond "Double-Edged Sword Effect" on Organic Room-Temperature Phosphorescence Properties: A Theoretical Perspective.
J Phys Chem A
January 2025
Shandong Province Key Laboratory of Medical Physics and Image Processing Technology, School of Physics and Electronics, Shandong Normal University, Jinan 250014, China.
The strategy of designing efficient room-temperature phosphorescence (RTP) emitters based on hydrogen bond interactions has attracted great attention in recent years. However, the regulation mechanism of the hydrogen bond on the RTP property remains unclear, and corresponding theoretical investigations are highly desired. Herein, the structure-property relationship and the internal mechanism of the hydrogen bond effect in regulating the RTP property are studied through the combination of quantum mechanics and molecular mechanics methods (QM/MM) coupled with the thermal vibration correlation function method.
View Article and Find Full Text PDFCritical Role of Tetrahedral Coordination in Determining the Polysulfide Conversion Efficiency on Spinel Oxides.
J Am Chem Soc
January 2025
Energy Research Institute@NTU (ERI@N), Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore639798 ,Singapore.
Understanding the structure-property relationship and the way in which catalysts facilitate polysulfide conversion is crucial for the rational design of lithium-sulfur (Li-S) battery catalysts. Herein, a series of NiAlO, CoAlO, and CuAlO spinel oxides with varying Ni, Co, or Cu tetrahedral and octahedral site occupancy are studied as Li-S battery catalysts. Combined with experimental and theoretical analysis, the tetrahedral site is identified as the most active site for enhancing polysulfide adsorption and charge transfer.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!