AI Article Synopsis
- Mesenchymal stem cells (MSCs) are being studied for their potential to treat autoimmune diseases, but their ability to move to the site of action (trafficking) is not fully understood.
- Disruption of the IL-6 gene or its signaling pathway impairs calcium channels needed for MSC migration, leading to weakened immunosuppressive function.
- This study reveals a critical relationship between IL-6 signaling and calcium channel activity, enhancing our understanding of how skin-derived MSCs function in the body.
Article Abstract
Mesenchymal stem cells (MSCs) have demonstrated promising therapeutic potential for a variety of diseases including autoimmune disorders. A fundamental requirement for MSC-mediated in vivo immunosuppression is their effective trafficking. However the mechanism underlying MSC trafficking remains elusive. Here we report that skin-derived MSCs (S-MSCs) secrete high levels of interleukin-6 (IL-6) in inflammatory conditions. Disruption of the il6 or its signaling transducer gp130 blocks voltage-gated calcium (Ca(2+) ) channels (VGCC) critically required for cell contraction involved in the sequential adhesion and de-adhesion events during S-MSC migration. Deletion of il6 gene leads to a severe defect in S-MSC's trafficking and immunosuppressive function in vivo. Thus, this unexpected requirement of autocrine IL-6 for activating Ca(2+) channels uncovers a previously unrecognized link between the IL-6 signaling and the VGCC and provides novel mechanistic insights for the trafficking and immunomodulatory activities of S-MSCs.
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| http://dx.doi.org/10.1002/stem.1763 | DOI Listing |
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