Medications can cause photosensitivity. Several of these medications, specifically the nonsteroidal anti-inflammatory medications (NSAIDs), may be taken by athletes to treat joint and muscle discomfort. Many athletic events occur outdoors, which in turn exposes athletes to sunlight. Athletes taking NSAIDs and performing extensive outdoor activities may be at higher risk for phototoxic drug reactions. Clinicians may wish consider the potential for patient photosensitivity when recommending prescription and non-prescription medications to outdoor athletes.
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http://dx.doi.org/10.1097/JSM.0000000000000119 | DOI Listing |
Ecotoxicol Environ Saf
December 2024
Centre de Recherche des Cordeliers, INSERM UMRS 1138, Université Paris Cité, Sorbonne Université. Team: Physiopathology of Ocular Diseases: Therapeutic Innovations. 15, rue de l'école de Médecine Paris 75006, France. Electronic address:
The exposure of the general population to artificial light at night has dramatically increased in recent decades. Current standards for domestic lighting are based on acute exposure to light and consider blue wavelengths to be responsible for phototoxicity. However, meta-analyses pointed out the role of lifelong light exposure in the onset of age-related macular degeneration, suggesting a cumulative effect of light exposure.
View Article and Find Full Text PDFIndian Dermatol Online J
October 2024
Department of Dermatology, Venereology and Leprosy, Dr. Radhakrishnan Government Medical College, Hamirpur, Himachal Pradesh, India.
Topical sunscreens decrease the quantity of ultraviolet (UV) light from the sun reaching the skin by either blocking or scattering it and help protect the skin from dyspigmentation, photoaging, DNA damage, and photocarcinogenesis, especially in photosensitive individuals. The significant role played by visible light and infrared light in skin pigmentation and photoaging has been recognized in recent years. The majority of broad-spectrum sunscreens protect against UV-B (290-320nm) and UV-A (320-400nm) radiation.
View Article and Find Full Text PDFMethods Mol Biol
September 2024
Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI, USA.
Zebrafish maintain a remarkable ability to regenerate their neural retina following rapid and extensive loss of retinal neurons. This is mediated by Müller glial cells (MG), which re-enter the cell cycle to produce amplifying progenitor cells that eventually differentiate into the lost retinal neurons. For example, exposing adult albino zebrafish to intense light destroys large numbers of rod and cone photoreceptors, which are then restored by MG-mediated regeneration.
View Article and Find Full Text PDFAltern Lab Anim
September 2024
Institute of Experimental Pharmacology and Toxicology (IEPT), Centre of Experimental Medicine (CEM), Slovak Academy of Sciences (SAS), Bratislava, Slovakia.
Front Cell Dev Biol
July 2024
CRTD-Center for Regenerative Therapies, and PoL-Cluster of Excellence Physics of Life, Dresden, Germany.
Inflammation can lead to persistent and irreversible loss of retinal neurons and photoreceptors in mammalian vertebrates. In contrast, in the adult zebrafish brain, acute neural inflammation is both necessary and sufficient to stimulate regeneration of neurons. Here, we report on the critical, positive role of the immune system to support retina regeneration in adult zebrafish.
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