AI Article Synopsis
- Flavanones like naringenin (NAR) and 8-prenylnaringenin (8-PN) may pose risks to female reproduction, with evidence showing they can negatively impact porcine oocyte maturation in vitro.
- At concentrations similar to those found in human plasma from supplements, NAR and 8-PN reduced key processes such as cumulus expansion, meiotic spindle formation, oocyte cleavage, and blastocyst formation.
- The study emphasizes caution against excessive consumption of these flavanones through dietary supplements, as abnormal oocyte maturation could lead to subfertility in women.
Article Abstract
Flavanones such as naringenin (NAR) and 8-prenylnaringenin (8-PN) are increasingly used as dietary supplements despite scientific concern regarding adverse effects on female reproduction upon excessive intake. In the present study, NAR and 8-PN (0.3-1μM) significantly affected porcine oocyte maturation in vitro by decreasing cumulus expansion. In addition, NAR and 8-PN decreased percentages of meiotic spindle formation, oocyte cleavage and blastocyst formation. The effects of NAR and 8-PN were different from estradiol (3.12μM)-induced effects. Still, the flavanone-induced effects were observed at concentrations that can be found in human plasma upon supplement intake and that resemble physiological estrogen equivalence levels in follicular fluids. Considering that abnormal oocyte maturation can cause subfertility, our study warrants that precautions are in place and excessive intake of NAR and 8-PN e.g. via dietary supplements should be avoided by women.
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| http://dx.doi.org/10.1016/j.reprotox.2014.05.013 | DOI Listing |
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